Exercise-induced asthma is not associated with mast cell activation or airway inflammation

Nizar N. Jarjour, William Calhoun, Carol A. Stevens, Steven M. Salisbury

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Exercise-induced asthma (EIA) may affect up to 90% of patients with asthma. Hyperpnea associated with exercise leads to increased airway water and heat loss, which contributes to the development of EIA. Measurement of circulating mediators has suggested that mast cells may participate in the development of EIA via release of histamine and neutrophil chemotactic factor. To evaluate further the contribution, of pulmonary mast cell-mediator release in the pathogenesis of EIA and to determine whether EIA is associated with enhancement of airway inflammation, we studied 11 subjects with mild stable asthma (FEV1, 93%±3% predicted; mean±SEM) with significant EIA (after exercise fall in FEV1, 41%±5%). Bronchoalveolar lavage (BAL) was performed immediately (less than 1 hour) after exercise challenge, (EC) and repeated 24 hours later (exercise studies). On another occasion, paired BALs were done 24 hours apart (control studies). A minimum of 2 weeks separated the exercise and control pairs. No changes were observed in BAL cell counts, differentials, or reactive oxygen species metabolism after EC. Neither BAL histamine nor BAL tryptase levels increased, either shourtly (less than 1 hour) or 24 hours after EC. We conclude that EC in subjects with asthma is not associated with cellular influx to airspace and that mechanisms other than histamine release by pulmonary mast cells may be responsible for EIA.

Original languageEnglish (US)
Pages (from-to)60-68
Number of pages9
JournalThe Journal of Allergy and Clinical Immunology
Volume89
Issue number1 PART 1
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Exercise-Induced Asthma
Mast Cells
Exercise
Inflammation
Bronchoalveolar Lavage
Asthma
Histamine Release
Tryptases
Dimercaprol
Lung
Interleukin-8
Histamine
Reactive Oxygen Species
Cell Count
Hot Temperature
Water

Keywords

  • asthma
  • bronchoprovocation
  • bronchoscopy
  • Exercise
  • histamine
  • mast cell

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Exercise-induced asthma is not associated with mast cell activation or airway inflammation. / Jarjour, Nizar N.; Calhoun, William; Stevens, Carol A.; Salisbury, Steven M.

In: The Journal of Allergy and Clinical Immunology, Vol. 89, No. 1 PART 1, 1992, p. 60-68.

Research output: Contribution to journalArticle

Jarjour, Nizar N. ; Calhoun, William ; Stevens, Carol A. ; Salisbury, Steven M. / Exercise-induced asthma is not associated with mast cell activation or airway inflammation. In: The Journal of Allergy and Clinical Immunology. 1992 ; Vol. 89, No. 1 PART 1. pp. 60-68.
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