Exercise plays a preventive role against Alzheimer's disease

Zsolt Radak, Nikoletta Hart, Linda Sarga, Erika Koltai, Mustafa Atalay, Hideki Ohno, Istvan Boldogh

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting the elderly population. It is predicted that the incidence of AD will be increased in the future making this disease one of the greatest medical, social, and economic challenges for individuals, families, and the health care system worldwide. The etiology of AD is multifactorial. It features increased oxidative state and deposition of amyloid plaques and neurofibrillary tangles of protein tau in the central cortex and limbic system of the brain. Here we provide an overview of the positive impacts of exercise on this challenging disease. Regular physical activity increases the endurance of cells and tissues to oxidative stress, vascularization, energy metabolism, and neurotrophin synthesis, all important in neurogenesis, memory improvement, and brain plasticity. Although extensive studies are required to understand the mechanism, it is clear that physical exercise is beneficial in the prevention of AD and other age-associated neurodegenerative disorders.

Original languageEnglish (US)
Pages (from-to)777-783
Number of pages7
JournalJournal of Alzheimer's Disease
Volume20
Issue number3
DOIs
StatePublished - 2010

Fingerprint

Alzheimer Disease
Exercise
Neurodegenerative Diseases
Medical Economics
tau Proteins
Limbic System
Neurofibrillary Tangles
Family Health
Neurogenesis
Amyloid Plaques
Nerve Growth Factors
Brain
Energy Metabolism
Oxidative Stress
Delivery of Health Care
Incidence
Population

Keywords

  • Amyloid-β
  • amyloid-β degradation
  • exercise
  • metabolism
  • neurotrophins
  • physical inactivity
  • sirtuins

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Exercise plays a preventive role against Alzheimer's disease. / Radak, Zsolt; Hart, Nikoletta; Sarga, Linda; Koltai, Erika; Atalay, Mustafa; Ohno, Hideki; Boldogh, Istvan.

In: Journal of Alzheimer's Disease, Vol. 20, No. 3, 2010, p. 777-783.

Research output: Contribution to journalArticle

Radak, Z, Hart, N, Sarga, L, Koltai, E, Atalay, M, Ohno, H & Boldogh, I 2010, 'Exercise plays a preventive role against Alzheimer's disease', Journal of Alzheimer's Disease, vol. 20, no. 3, pp. 777-783. https://doi.org/10.3233/JAD-2010-091531
Radak, Zsolt ; Hart, Nikoletta ; Sarga, Linda ; Koltai, Erika ; Atalay, Mustafa ; Ohno, Hideki ; Boldogh, Istvan. / Exercise plays a preventive role against Alzheimer's disease. In: Journal of Alzheimer's Disease. 2010 ; Vol. 20, No. 3. pp. 777-783.
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