Exercise, redox system and neurodegenerative diseases

Helong Quan; Erika Koltai; Katsuhiko Suzuki; Aderbal S. Aguiar; Ricardo Pinho; Istvan Boldogh; Istvan Berkes; Zsolt Radak

doi:10.1016/j.bbadis.2020.165778

Exercise, redox system and neurodegenerative diseases

Helong Quan, Erika Koltai, Katsuhiko Suzuki, Aderbal S. Aguiar, Ricardo Pinho, Istvan Boldogh, Istvan Berkes, Zsolt Radak

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

Regular exercise induces a wide range of redox system-associated molecular adaptive responses to the nervous system. The intermittent induction of reactive oxygen species (ROS) during acute exercise sessions and the related upregulation of antioxidant/repair and housekeeping systems are associated with improved physiological function. Exercise-induced proliferation and differentiation of neuronal stem cells are ROS dependent processes. The increased production of brain derived neurotrophic factor (BDNF) and the regulation by regular exercise are dependent upon redox sensitive pathways. ROS are causative and associative factors of neurodegenerative diseases and regular exercise provides significant neuroprotective effects against Alzheimer's disease, Parkinson's disease, and hypoxia/reperfusion related disorders. Regular exercise regulates redox homeostasis in the brain with complex multi-level molecular pathways.

Original language	English (US)
Article number	165778
Journal	Biochimica et Biophysica Acta - Molecular Basis of Disease
Volume	1866
Issue number	10
DOIs	https://doi.org/10.1016/j.bbadis.2020.165778
State	Published - Oct 1 2020

Keywords

Alzheimer diseases
Brain function
Exercise
Ischemia reperfusion
Neuroprotection
Parkinson's disease
Redox homeostasis

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology

Access to Document

10.1016/j.bbadis.2020.165778

Cite this

@article{af68a1e8e7134443b71c39cfdc495102,

title = "Exercise, redox system and neurodegenerative diseases",

abstract = "Regular exercise induces a wide range of redox system-associated molecular adaptive responses to the nervous system. The intermittent induction of reactive oxygen species (ROS) during acute exercise sessions and the related upregulation of antioxidant/repair and housekeeping systems are associated with improved physiological function. Exercise-induced proliferation and differentiation of neuronal stem cells are ROS dependent processes. The increased production of brain derived neurotrophic factor (BDNF) and the regulation by regular exercise are dependent upon redox sensitive pathways. ROS are causative and associative factors of neurodegenerative diseases and regular exercise provides significant neuroprotective effects against Alzheimer's disease, Parkinson's disease, and hypoxia/reperfusion related disorders. Regular exercise regulates redox homeostasis in the brain with complex multi-level molecular pathways.",

keywords = "Alzheimer diseases, Brain function, Exercise, Ischemia reperfusion, Neuroprotection, Parkinson's disease, Redox homeostasis",

author = "Helong Quan and Erika Koltai and Katsuhiko Suzuki and Aguiar, {Aderbal S.} and Ricardo Pinho and Istvan Boldogh and Istvan Berkes and Zsolt Radak",

note = "Funding Information: This study was supported by OTKA ( 112810 ) and National Excellence Program ( 126823 ), and Scientific Excellence Program TUDFO/51757/2019-ITM , at the University of Physical Education, Innovation and Technology Ministry, Hungary, grants awarded to Z.R. Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = oct,

day = "1",

doi = "10.1016/j.bbadis.2020.165778",

language = "English (US)",

volume = "1866",

journal = "Biochimica et Biophysica Acta - Molecular Basis of Disease",

issn = "0925-4439",

publisher = "Elsevier",

number = "10",

}

TY - JOUR

T1 - Exercise, redox system and neurodegenerative diseases

AU - Quan, Helong

AU - Koltai, Erika

AU - Suzuki, Katsuhiko

AU - Aguiar, Aderbal S.

AU - Pinho, Ricardo

AU - Boldogh, Istvan

AU - Berkes, Istvan

AU - Radak, Zsolt

N1 - Funding Information: This study was supported by OTKA ( 112810 ) and National Excellence Program ( 126823 ), and Scientific Excellence Program TUDFO/51757/2019-ITM , at the University of Physical Education, Innovation and Technology Ministry, Hungary, grants awarded to Z.R. Publisher Copyright: © 2020 The Author(s)

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Regular exercise induces a wide range of redox system-associated molecular adaptive responses to the nervous system. The intermittent induction of reactive oxygen species (ROS) during acute exercise sessions and the related upregulation of antioxidant/repair and housekeeping systems are associated with improved physiological function. Exercise-induced proliferation and differentiation of neuronal stem cells are ROS dependent processes. The increased production of brain derived neurotrophic factor (BDNF) and the regulation by regular exercise are dependent upon redox sensitive pathways. ROS are causative and associative factors of neurodegenerative diseases and regular exercise provides significant neuroprotective effects against Alzheimer's disease, Parkinson's disease, and hypoxia/reperfusion related disorders. Regular exercise regulates redox homeostasis in the brain with complex multi-level molecular pathways.

AB - Regular exercise induces a wide range of redox system-associated molecular adaptive responses to the nervous system. The intermittent induction of reactive oxygen species (ROS) during acute exercise sessions and the related upregulation of antioxidant/repair and housekeeping systems are associated with improved physiological function. Exercise-induced proliferation and differentiation of neuronal stem cells are ROS dependent processes. The increased production of brain derived neurotrophic factor (BDNF) and the regulation by regular exercise are dependent upon redox sensitive pathways. ROS are causative and associative factors of neurodegenerative diseases and regular exercise provides significant neuroprotective effects against Alzheimer's disease, Parkinson's disease, and hypoxia/reperfusion related disorders. Regular exercise regulates redox homeostasis in the brain with complex multi-level molecular pathways.

KW - Alzheimer diseases

KW - Brain function

KW - Exercise

KW - Ischemia reperfusion

KW - Neuroprotection

KW - Parkinson's disease

KW - Redox homeostasis

UR - http://www.scopus.com/inward/record.url?scp=85086404639&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85086404639&partnerID=8YFLogxK

U2 - 10.1016/j.bbadis.2020.165778

DO - 10.1016/j.bbadis.2020.165778

M3 - Review article

C2 - 32222542

AN - SCOPUS:85086404639

SN - 0925-4439

VL - 1866

JO - Biochimica et Biophysica Acta - Molecular Basis of Disease

JF - Biochimica et Biophysica Acta - Molecular Basis of Disease

IS - 10

M1 - 165778

ER -

Exercise, redox system and neurodegenerative diseases

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this