Exercise, redox system and neurodegenerative diseases

Helong Quan, Erika Koltai, Katsuhiko Suzuki, Aderbal S. Aguiar, Ricardo Pinho, Istvan Boldogh, Istvan Berkes, Zsolt Radak

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Regular exercise induces a wide range of redox system-associated molecular adaptive responses to the nervous system. The intermittent induction of reactive oxygen species (ROS) during acute exercise sessions and the related upregulation of antioxidant/repair and housekeeping systems are associated with improved physiological function. Exercise-induced proliferation and differentiation of neuronal stem cells are ROS dependent processes. The increased production of brain derived neurotrophic factor (BDNF) and the regulation by regular exercise are dependent upon redox sensitive pathways. ROS are causative and associative factors of neurodegenerative diseases and regular exercise provides significant neuroprotective effects against Alzheimer's disease, Parkinson's disease, and hypoxia/reperfusion related disorders. Regular exercise regulates redox homeostasis in the brain with complex multi-level molecular pathways.

Original languageEnglish (US)
Article number165778
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Issue number10
StatePublished - Oct 1 2020


  • Alzheimer diseases
  • Brain function
  • Exercise
  • Ischemia reperfusion
  • Neuroprotection
  • Parkinson's disease
  • Redox homeostasis

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology


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