Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats

Mohammad Mosaferi Ziaaldini, Erika Koltai, Zsolt Csende, Sataro Goto, Istvan Boldogh, Albert W. Taylor, Zsolt Radak

Research output: Contribution to journalArticle

36 Scopus citations


Aging results in significant loss of mass and function of the skeletal muscle, which negatively impacts the quality of life. In this study we investigated whether aerobic exercise training has the potential to alter anabolic and catabolic pathways in the skeletal muscle. Five and twenty eight month old rats were used in the study. Aging resulted in decreased levels of follistatin/mTOR/Akt/Erk activation and increased myostatin/Murf1/2, proteasome subunits, and protein ubiquitination levels. In addition, TNF-α, reactive oxygen species (ROS), p53, and Bax levels were increased while Bcl-2 levels were decreased in the skeletal muscle of aged rats. Six weeks of exercise training at 60% of VO2max reversed the age-associated activation of catabolic and apoptotic pathways and increased anabolic signaling. The results suggest that the age-associated loss of muscle mass and cachexia could be due to the orchestrated down-regulation of anabolic and up-regulation of catabolic and pro-apoptotic processes. These metabolic changes can be attenuated by exercise training.

Original languageEnglish (US)
Pages (from-to)9-14
Number of pages6
JournalExperimental Gerontology
StatePublished - Jul 1 2015



  • Aging
  • Exercise
  • Follistatin
  • Myostatin
  • Reactive oxygen species
  • Skeletal muscle

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Genetics
  • Molecular Biology

Cite this