Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats

Mohammad Mosaferi Ziaaldini, Erika Koltai, Zsolt Csende, Sataro Goto, Istvan Boldogh, Albert W. Taylor, Zsolt Radak

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Aging results in significant loss of mass and function of the skeletal muscle, which negatively impacts the quality of life. In this study we investigated whether aerobic exercise training has the potential to alter anabolic and catabolic pathways in the skeletal muscle. Five and twenty eight month old rats were used in the study. Aging resulted in decreased levels of follistatin/mTOR/Akt/Erk activation and increased myostatin/Murf1/2, proteasome subunits, and protein ubiquitination levels. In addition, TNF-α, reactive oxygen species (ROS), p53, and Bax levels were increased while Bcl-2 levels were decreased in the skeletal muscle of aged rats. Six weeks of exercise training at 60% of VO2max reversed the age-associated activation of catabolic and apoptotic pathways and increased anabolic signaling. The results suggest that the age-associated loss of muscle mass and cachexia could be due to the orchestrated down-regulation of anabolic and up-regulation of catabolic and pro-apoptotic processes. These metabolic changes can be attenuated by exercise training.

Original languageEnglish (US)
Pages (from-to)9-14
Number of pages6
JournalExperimental Gerontology
Volume67
DOIs
StatePublished - Jul 1 2015

Fingerprint

Muscle
Rats
Skeletal Muscle
Exercise
Aging of materials
Chemical activation
Myostatin
Follistatin
Cachexia
Ubiquitination
Protein Subunits
Proteasome Endopeptidase Complex
Reactive Oxygen Species
Up-Regulation
Down-Regulation
Quality of Life
Muscles

Keywords

  • Aging
  • Exercise
  • Follistatin
  • Myostatin
  • Reactive oxygen species
  • Skeletal muscle

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Genetics
  • Molecular Biology

Cite this

Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats. / Ziaaldini, Mohammad Mosaferi; Koltai, Erika; Csende, Zsolt; Goto, Sataro; Boldogh, Istvan; Taylor, Albert W.; Radak, Zsolt.

In: Experimental Gerontology, Vol. 67, 01.07.2015, p. 9-14.

Research output: Contribution to journalArticle

Ziaaldini, Mohammad Mosaferi ; Koltai, Erika ; Csende, Zsolt ; Goto, Sataro ; Boldogh, Istvan ; Taylor, Albert W. ; Radak, Zsolt. / Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats. In: Experimental Gerontology. 2015 ; Vol. 67. pp. 9-14.
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