TY - JOUR
T1 - Exercise training modifies ghrelin and adiponectin concentrations and is related to inflammation in older adults
AU - Markofski, Melissa M.
AU - Carrillo, Andres E.
AU - Timmerman, Kyle L.
AU - Jennings, Kristofer
AU - Coen, Paul M.
AU - Pence, Brandt D.
AU - Flynn, Michael G.
N1 - Funding Information:
Funding This work was funded by an American Association of Retired Persons (AARP) Scholars Program Award granted by AARP’s Office of Academic Affairs and internal support from the Department of Health and Kinesiology at Purdue University.
PY - 2014/6
Y1 - 2014/6
N2 - The purpose of this study was to observe exercise training-induced effects on adiponectin, leptin, and ghrelin. Twenty-nine older, healthy participants were classified as physically active (comparison group: N = 15, 70.9±1.2 years) or physically inactive (exercise group: N = 14, 70.5±1.4 years). Exercise group participants completed 12 weeks of combined aerobic and resistance exercise training, whereas comparison group participants maintained their current level of exercise and served as a physically active comparison group. Monocyte phenotype, as well as serum ghrelin, leptin, adiponectin, and soluble tumor necrosis factor receptor II were analyzed prior to and following the 12-week period. Ghrelin and adiponectin increased 47% and 55%, respectively, in exercise group participants following exercise training. Percent change in ghrelin (post and pre) was negatively correlated with the percent change in CD14+CD16+ monocytes (post and pre) in exercise group participants. Despite no changes in body mass, these data contribute to evidence for the anti-inflammatory effects of exercise.
AB - The purpose of this study was to observe exercise training-induced effects on adiponectin, leptin, and ghrelin. Twenty-nine older, healthy participants were classified as physically active (comparison group: N = 15, 70.9±1.2 years) or physically inactive (exercise group: N = 14, 70.5±1.4 years). Exercise group participants completed 12 weeks of combined aerobic and resistance exercise training, whereas comparison group participants maintained their current level of exercise and served as a physically active comparison group. Monocyte phenotype, as well as serum ghrelin, leptin, adiponectin, and soluble tumor necrosis factor receptor II were analyzed prior to and following the 12-week period. Ghrelin and adiponectin increased 47% and 55%, respectively, in exercise group participants following exercise training. Percent change in ghrelin (post and pre) was negatively correlated with the percent change in CD14+CD16+ monocytes (post and pre) in exercise group participants. Despite no changes in body mass, these data contribute to evidence for the anti-inflammatory effects of exercise.
KW - Adipokine
KW - Anti-inflammatory
KW - Inflammation
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U2 - 10.1093/gerona/glt132
DO - 10.1093/gerona/glt132
M3 - Article
C2 - 24013674
AN - SCOPUS:84901036420
SN - 1079-5006
VL - 69
SP - 675
EP - 681
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 6
ER -