Exfoliative diseases of the integument and soft tissue necrotizing infections

Shawn P. Fagan, Joshua Carson, Carlos Jimenez, Jiake Chai, Marcus Spies, Maureen Hollyoak, Michael J. Muller, Cleon W. Goodwin, David N. Herndon

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Acute, severe exfoliative, and necrotizing diseases of skin and underlying structures may cause significant morbidity in the afflicted patient. The problems associated with these diseases, such as wound infection, sepsis, inadequate nutrition, and pain, are similar to those seen in patients with major burns. These patients, however, are often more acutely ill than burn patients due to the involvement of more internal surfaces and systems. Burn centers provide expertise in the treatment and management of critically ill patients with skin loss from all causes, not solely from thermal injury. This chapter describes the pathophysiological processes of severe exfoliative skin disorders, their diagnosis, and the specialized treatment offered by burn units.

Original languageEnglish (US)
Title of host publicationTotal Burn Care
Subtitle of host publicationFifth Edition
PublisherElsevier Inc.
ISBN (Electronic)9780323497428
ISBN (Print)9780323476614
StatePublished - 2018


  • Calciphylaxis
  • Exfoliative diseases of skin
  • Necrotizing diseases of skin
  • Necrotizing fasciitis
  • Purpura fulminans
  • Staphylococcal scalded skin syndrome
  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis

ASJC Scopus subject areas

  • General Medicine


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