Exosomes and their role in the life cycle and pathogenesis of RNA viruses

Harendra Singh Chahar, Xiaoyong Bao, Antonella Casola

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Exosomes are membrane-enclosed vesicles actively released into the extracellular space, whose content reflect the physiological/pathological state of the cells they originate from. These vesicles participate in cell-to-cell communication and transfer of biologically active proteins, lipids, and RNAs. Their role in viral infections is just beginning to be appreciated. RNA viruses are an important class of pathogens and affect millions of people worldwide. Recent studies on Human Immunodeficiency Virus (HIV), Hepatitis C Virus (HCV), human T-cell lymphotropic virus (HTLV), and Dengue Virus (DENV) have demonstrated that exosomes released from infected cells harbor and deliver many regulatory factors including viral RNA and proteins, viral and cellular miRNA, and other host functional genetic elements to neighboring cells, helping to establish productive infections and modulating cellular responses. Exosomes can either spread or limit an infection depending on the type of pathogen and target cells, and can be exploited as candidates for development of antiviral or vaccine treatments. This review summarizes recent progress made in understanding the role of exosomes in RNA virus infections with an emphasis on their potential contribution to pathogenesis.

Original languageEnglish (US)
Pages (from-to)3204-3225
Number of pages22
JournalViruses
Volume7
Issue number6
DOIs
StatePublished - Jun 19 2015

Fingerprint

Exosomes
RNA Viruses
Life Cycle Stages
RNA Virus Infections
Dengue Virus
Viral RNA
Extracellular Space
Viral Proteins
Virus Diseases
Infection
MicroRNAs
Cell Communication
Hepacivirus
Antiviral Agents
Vaccines
HIV
RNA
Viruses
T-Lymphocytes
Lipids

Keywords

  • Exosomes
  • Infection
  • Microvesicles
  • MiRNA
  • Pathogenesis
  • RNA virus

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Exosomes and their role in the life cycle and pathogenesis of RNA viruses. / Chahar, Harendra Singh; Bao, Xiaoyong; Casola, Antonella.

In: Viruses, Vol. 7, No. 6, 19.06.2015, p. 3204-3225.

Research output: Contribution to journalArticle

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