Exotic emerging viral diseases

Progress and challenges

Thomas Geisbert, Peter B. Jahrling

Research output: Contribution to journalArticle

336 Citations (Scopus)

Abstract

The agents causing viral hemorrhagic fever (VHF) are a taxonomically diverse group of viruses that may share commonalities in the process whereby they produce systemic and frequently fatal disease. Significant progress has been made in understanding the biology of the Ebola virus, one of the best known examples. This knowledge has guided our thinking about other VHF agents, including Marburg, Lassa, the South American arenaviruses, yellow fever, Crimean-Congo and Rift Valley fever viruses. Comparisons among VHFs show that a common pathogenic feature is their ability to disable the host immune response by attacking and manipulating the cells that initiate the antiviral response. Of equal importance, these comparisons highlight critical gaps in our knowledge of these pathogens.

Original languageEnglish (US)
JournalNature Medicine
Volume10
Issue number12 SUPPL.
DOIs
StatePublished - Dec 2004
Externally publishedYes

Fingerprint

Viral Hemorrhagic Fevers
Virus Diseases
Viruses
Rift Valley fever virus
Arenavirus
Ebolavirus
Congo
Yellow Fever
Antiviral Agents
Pathogens

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Exotic emerging viral diseases : Progress and challenges. / Geisbert, Thomas; Jahrling, Peter B.

In: Nature Medicine, Vol. 10, No. 12 SUPPL., 12.2004.

Research output: Contribution to journalArticle

Geisbert, Thomas ; Jahrling, Peter B. / Exotic emerging viral diseases : Progress and challenges. In: Nature Medicine. 2004 ; Vol. 10, No. 12 SUPPL.
@article{fe9db7d2fdd442c284cca0fcec6587d4,
title = "Exotic emerging viral diseases: Progress and challenges",
abstract = "The agents causing viral hemorrhagic fever (VHF) are a taxonomically diverse group of viruses that may share commonalities in the process whereby they produce systemic and frequently fatal disease. Significant progress has been made in understanding the biology of the Ebola virus, one of the best known examples. This knowledge has guided our thinking about other VHF agents, including Marburg, Lassa, the South American arenaviruses, yellow fever, Crimean-Congo and Rift Valley fever viruses. Comparisons among VHFs show that a common pathogenic feature is their ability to disable the host immune response by attacking and manipulating the cells that initiate the antiviral response. Of equal importance, these comparisons highlight critical gaps in our knowledge of these pathogens.",
author = "Thomas Geisbert and Jahrling, {Peter B.}",
year = "2004",
month = "12",
doi = "10.1038/nm1142",
language = "English (US)",
volume = "10",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "12 SUPPL.",

}

TY - JOUR

T1 - Exotic emerging viral diseases

T2 - Progress and challenges

AU - Geisbert, Thomas

AU - Jahrling, Peter B.

PY - 2004/12

Y1 - 2004/12

N2 - The agents causing viral hemorrhagic fever (VHF) are a taxonomically diverse group of viruses that may share commonalities in the process whereby they produce systemic and frequently fatal disease. Significant progress has been made in understanding the biology of the Ebola virus, one of the best known examples. This knowledge has guided our thinking about other VHF agents, including Marburg, Lassa, the South American arenaviruses, yellow fever, Crimean-Congo and Rift Valley fever viruses. Comparisons among VHFs show that a common pathogenic feature is their ability to disable the host immune response by attacking and manipulating the cells that initiate the antiviral response. Of equal importance, these comparisons highlight critical gaps in our knowledge of these pathogens.

AB - The agents causing viral hemorrhagic fever (VHF) are a taxonomically diverse group of viruses that may share commonalities in the process whereby they produce systemic and frequently fatal disease. Significant progress has been made in understanding the biology of the Ebola virus, one of the best known examples. This knowledge has guided our thinking about other VHF agents, including Marburg, Lassa, the South American arenaviruses, yellow fever, Crimean-Congo and Rift Valley fever viruses. Comparisons among VHFs show that a common pathogenic feature is their ability to disable the host immune response by attacking and manipulating the cells that initiate the antiviral response. Of equal importance, these comparisons highlight critical gaps in our knowledge of these pathogens.

UR - http://www.scopus.com/inward/record.url?scp=10944235503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10944235503&partnerID=8YFLogxK

U2 - 10.1038/nm1142

DO - 10.1038/nm1142

M3 - Article

VL - 10

JO - Nature Medicine

JF - Nature Medicine

SN - 1078-8956

IS - 12 SUPPL.

ER -