Expanding the physiological role of the hexameric DnaB helicase

Wlodzimierz Bujalowski

    Research output: Contribution to journalShort surveypeer-review

    17 Scopus citations


    The hexameric DnaB protein is the Escherichia coli primary replicative helicase. However, recent studies indicate that this enzyme is capable of driving branch migration of a Holliday junction, acting more like an ATP-driven pump than a helicase. This offers an attractive possibility that the protein is directly involved in DNA recombination in vivo. Thus, the physiological role of the DnaB protein in DNA metabolism, and its modes of action, might be more complex than previously thought.

    Original languageEnglish (US)
    Pages (from-to)116-118
    Number of pages3
    JournalTrends in biochemical sciences
    Issue number3
    StatePublished - Mar 1 2003

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology


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