Expanding the physiological role of the hexameric DnaB helicase

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The hexameric DnaB protein is the Escherichia coli primary replicative helicase. However, recent studies indicate that this enzyme is capable of driving branch migration of a Holliday junction, acting more like an ATP-driven pump than a helicase. This offers an attractive possibility that the protein is directly involved in DNA recombination in vivo. Thus, the physiological role of the DnaB protein in DNA metabolism, and its modes of action, might be more complex than previously thought.

Original languageEnglish (US)
Pages (from-to)116-118
Number of pages3
JournalTrends in Biochemical Sciences
Volume28
Issue number3
DOIs
StatePublished - Mar 1 2003

Fingerprint

DnaB Helicases
Cruciform DNA
Escherichia coli Proteins
DNA
Genetic Recombination
Proteins
Adenosine Triphosphate
Metabolism
Escherichia coli
Enzymes
Pumps

ASJC Scopus subject areas

  • Biochemistry

Cite this

Expanding the physiological role of the hexameric DnaB helicase. / Bujalowski, Wlodzimierz.

In: Trends in Biochemical Sciences, Vol. 28, No. 3, 01.03.2003, p. 116-118.

Research output: Contribution to journalArticle

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