Expanding the physiological role of the hexameric DnaB helicase

Wlodzimierz Bujalowski

doi:10.1016/S0968-0004(03)00034-3

Expanding the physiological role of the hexameric DnaB helicase

Wlodzimierz Bujalowski

Biochemistry & Molecular Biology

Research output: Contribution to journal › Short survey › peer-review

18 Scopus citations

Abstract

The hexameric DnaB protein is the Escherichia coli primary replicative helicase. However, recent studies indicate that this enzyme is capable of driving branch migration of a Holliday junction, acting more like an ATP-driven pump than a helicase. This offers an attractive possibility that the protein is directly involved in DNA recombination in vivo. Thus, the physiological role of the DnaB protein in DNA metabolism, and its modes of action, might be more complex than previously thought.

Original language	English (US)
Pages (from-to)	116-118
Number of pages	3
Journal	Trends in biochemical sciences
Volume	28
Issue number	3
DOIs	https://doi.org/10.1016/S0968-0004(03)00034-3
State	Published - Mar 1 2003

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/S0968-0004(03)00034-3

Cite this

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title = "Expanding the physiological role of the hexameric DnaB helicase",

abstract = "The hexameric DnaB protein is the Escherichia coli primary replicative helicase. However, recent studies indicate that this enzyme is capable of driving branch migration of a Holliday junction, acting more like an ATP-driven pump than a helicase. This offers an attractive possibility that the protein is directly involved in DNA recombination in vivo. Thus, the physiological role of the DnaB protein in DNA metabolism, and its modes of action, might be more complex than previously thought.",

author = "Wlodzimierz Bujalowski",

note = "Funding Information: This work was supported by NIH Grant GM–46679.",

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AU - Bujalowski, Wlodzimierz

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Y1 - 2003/3/1

N2 - The hexameric DnaB protein is the Escherichia coli primary replicative helicase. However, recent studies indicate that this enzyme is capable of driving branch migration of a Holliday junction, acting more like an ATP-driven pump than a helicase. This offers an attractive possibility that the protein is directly involved in DNA recombination in vivo. Thus, the physiological role of the DnaB protein in DNA metabolism, and its modes of action, might be more complex than previously thought.

AB - The hexameric DnaB protein is the Escherichia coli primary replicative helicase. However, recent studies indicate that this enzyme is capable of driving branch migration of a Holliday junction, acting more like an ATP-driven pump than a helicase. This offers an attractive possibility that the protein is directly involved in DNA recombination in vivo. Thus, the physiological role of the DnaB protein in DNA metabolism, and its modes of action, might be more complex than previously thought.

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M3 - Short survey

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JO - Trends in biochemical sciences

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Expanding the physiological role of the hexameric DnaB helicase

Abstract

ASJC Scopus subject areas

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