Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines

Key precursors to potent c-Met inhibitors

Yuanxiang Wang, Jing Ai, Gang Liu, Meiyu Geng, Ao Zhang

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

An effective one-pot synthesis of quinolines bearing diverse C3-piperazinyl functions was developed by using a modified Friedländer's protocol. The method not only enables the synthesis of our early reported c-Met inhibitor on a large scale, but also provides a way to generate novel multi-substituted quinolines for further structure-activity relationship (SAR) study.

Original languageEnglish (US)
Pages (from-to)5930-5933
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume9
Issue number17
DOIs
StatePublished - Sep 7 2011
Externally publishedYes

Fingerprint

Quinolines
quinoline
inhibitors
Bearings (structural)
Structure-Activity Relationship
synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines : Key precursors to potent c-Met inhibitors. / Wang, Yuanxiang; Ai, Jing; Liu, Gang; Geng, Meiyu; Zhang, Ao.

In: Organic and Biomolecular Chemistry, Vol. 9, No. 17, 07.09.2011, p. 5930-5933.

Research output: Contribution to journalArticle

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