Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: Key precursors to potent c-Met inhibitors

Yuanxiang Wang; Jing Ai; Gang Liu; Meiyu Geng; Ao Zhang

doi:10.1039/c1ob05830d

Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: Key precursors to potent c-Met inhibitors

Yuanxiang Wang, Jing Ai, Gang Liu, Meiyu Geng, Ao Zhang

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

An effective one-pot synthesis of quinolines bearing diverse C3-piperazinyl functions was developed by using a modified Friedländer's protocol. The method not only enables the synthesis of our early reported c-Met inhibitor on a large scale, but also provides a way to generate novel multi-substituted quinolines for further structure-activity relationship (SAR) study.

Original language	English (US)
Pages (from-to)	5930-5933
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	17
DOIs	https://doi.org/10.1039/c1ob05830d
State	Published - Sep 7 2011
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c1ob05830d

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abstract = "An effective one-pot synthesis of quinolines bearing diverse C3-piperazinyl functions was developed by using a modified Friedl{\"a}nder's protocol. The method not only enables the synthesis of our early reported c-Met inhibitor on a large scale, but also provides a way to generate novel multi-substituted quinolines for further structure-activity relationship (SAR) study.",

author = "Yuanxiang Wang and Jing Ai and Gang Liu and Meiyu Geng and Ao Zhang",

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AU - Geng, Meiyu

AU - Zhang, Ao

PY - 2011/9/7

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AB - An effective one-pot synthesis of quinolines bearing diverse C3-piperazinyl functions was developed by using a modified Friedländer's protocol. The method not only enables the synthesis of our early reported c-Met inhibitor on a large scale, but also provides a way to generate novel multi-substituted quinolines for further structure-activity relationship (SAR) study.

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Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: Key precursors to potent c-Met inhibitors

Abstract

ASJC Scopus subject areas

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