Abstract
An effective one-pot synthesis of quinolines bearing diverse C3-piperazinyl functions was developed by using a modified Friedländer's protocol. The method not only enables the synthesis of our early reported c-Met inhibitor on a large scale, but also provides a way to generate novel multi-substituted quinolines for further structure-activity relationship (SAR) study.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5930-5933 |
| Number of pages | 4 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 9 |
| Issue number | 17 |
| DOIs | |
| State | Published - Sep 7 2011 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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