Experimental aneurysm models

Visish M. Srinivasan, Peter Kan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Aneurysmal subarachnoid hemorrhage is a major cause of morbidity and mortality, with aneurysms affecting 1% of the population and causing 30,000 annual cases of rupture in the United States. While we have made large leaps forward in understanding the aneurysmal pathophysiology and used this knowledge to improve devices and treatment options, it is important to return to the bench in order to make major breakthroughs. All such major research hinges on the use of a good experimental model, which should be easy to use, cost effective, and reliably recapitulate the disease in patients. In this chapter, we review a variety of historical and modern experimental aneurysm models and their use. Finally, we discuss future aneurysmal research and the models that may help address those challenges.

Original languageEnglish (US)
Title of host publicationIntracranial Aneurysms
PublisherElsevier
Pages33-46
Number of pages14
ISBN (Electronic)9780128117408
ISBN (Print)9780128118832
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Keywords

  • Endovascular therapy
  • Flow diversion
  • Flow diverter
  • Intracranial aneurysm
  • Pipeline

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Srinivasan, V. M., & Kan, P. (2018). Experimental aneurysm models. In Intracranial Aneurysms (pp. 33-46). Elsevier. https://doi.org/10.1016/B978-0-12-811740-8.00003-4