Experimental everglades virus infection of cotton rats (Sigmodon hispidus)

Lark L. Coffey, Anne Sophie Carrara, Slobodan Paessler, Michelle L. Haynie, Robert D. Bradley, Robert B. Tesh, Scott Weaver

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Everglades virus (EVEV), an alphavirus in the Venezuelan equine encephalitis (VEE) serocomplex, circulates among rodents and vector mosquitoes and infects humans, causing a febrile disease sometimes accompanied by neurologic manifestations. EVEV circulates near metropolitan Miami, which indicates the potential for substantial human disease, should outbreaks arise. We characterized EVEV infection of cotton rats in South Florida, USA to validate their role in enzootic transmission. To evaluate whether the viremia induced in cotton rat populations regulates EVEV distribution, we also infected rats from a non-EVEV-endemic area. Viremia levels developed in rats from both localities that exceeded the threshold for infection of the vector. Most animals survived infection with no signs of illness, despite virus invasion of the brain and the development of mild encephalitis. Understanding the mechanisms by which EVEV-infected cotton rats resist clinical disease may be useful in developing VEE therapeutics for equines and humans.

Original languageEnglish (US)
Pages (from-to)2182-2188
Number of pages7
JournalEmerging Infectious Diseases
Volume10
Issue number12
StatePublished - Dec 2004

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Sigmodontinae
Virus Diseases
Viruses
Venezuelan Equine Encephalomyelitides
Viremia
Alphavirus
Encephalitis
Neurologic Manifestations
Infection
Disease Outbreaks
Rodentia
Fever
Brain
Population

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Coffey, L. L., Carrara, A. S., Paessler, S., Haynie, M. L., Bradley, R. D., Tesh, R. B., & Weaver, S. (2004). Experimental everglades virus infection of cotton rats (Sigmodon hispidus). Emerging Infectious Diseases, 10(12), 2182-2188.

Experimental everglades virus infection of cotton rats (Sigmodon hispidus). / Coffey, Lark L.; Carrara, Anne Sophie; Paessler, Slobodan; Haynie, Michelle L.; Bradley, Robert D.; Tesh, Robert B.; Weaver, Scott.

In: Emerging Infectious Diseases, Vol. 10, No. 12, 12.2004, p. 2182-2188.

Research output: Contribution to journalArticle

Coffey, LL, Carrara, AS, Paessler, S, Haynie, ML, Bradley, RD, Tesh, RB & Weaver, S 2004, 'Experimental everglades virus infection of cotton rats (Sigmodon hispidus)', Emerging Infectious Diseases, vol. 10, no. 12, pp. 2182-2188.
Coffey LL, Carrara AS, Paessler S, Haynie ML, Bradley RD, Tesh RB et al. Experimental everglades virus infection of cotton rats (Sigmodon hispidus). Emerging Infectious Diseases. 2004 Dec;10(12):2182-2188.
Coffey, Lark L. ; Carrara, Anne Sophie ; Paessler, Slobodan ; Haynie, Michelle L. ; Bradley, Robert D. ; Tesh, Robert B. ; Weaver, Scott. / Experimental everglades virus infection of cotton rats (Sigmodon hispidus). In: Emerging Infectious Diseases. 2004 ; Vol. 10, No. 12. pp. 2182-2188.
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