Abstract
Truncal vagotomy results in diminisched pancreatic protein secretion in response to intraduodenal fat. This diminished secretion may be due, at least in part, to interruption of the vagal reflexes between the intestine and the pancreas that work independently of cholecystokinin (CCK). In five dogs with chronic pancreatic fistulas, plasma CCK concentrations and pancreatic protein secretion in response to an intestinal stimulant (intraduodenal oleate) and to two exogenous peptides (bombesin and CCK-33) were compared before and after bilateral truncal vagotomy. Vagotomy decreased integrated protein secretion by about 50% in response to intraduodenal oleate. In contrast, protein output in response to parenteral stimuli increased after vagotomy. Integrated output of CCK in response to intraduodenal oleate or to exogenous bombesin or CCK was not significantly affected by vagotomy, but release of pancreatic polypeptide was decreased significantly in response to all stimuli after truncal vagotomy. These data provide evidence that truncal vagotomy decreases pancreatic protein secretion in response to intestinal stimulants by interrupting enteropancreatic reflexes mediated by the vagus, while maintaining normal (or supranormal) sensitivity of the pancreas to endogenous and exogenous CCK.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 69-74 |
| Number of pages | 6 |
| Journal | Annals of Surgery |
| Volume | 202 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1985 |
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ASJC Scopus subject areas
- Surgery
Cite this
Experimental evidence for a vagally mediated and cholecystokinin-independent enteropancreatic reflex. / Fried, G. M.; Ogden, W. D.; Sakamoto, T.; Greeley, G. H.; Thompson, J. C.
In: Annals of Surgery, Vol. 202, No. 1, 1985, p. 69-74.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Experimental evidence for a vagally mediated and cholecystokinin-independent enteropancreatic reflex
AU - Fried, G. M.
AU - Ogden, W. D.
AU - Sakamoto, T.
AU - Greeley, G. H.
AU - Thompson, J. C.
PY - 1985
Y1 - 1985
N2 - Truncal vagotomy results in diminisched pancreatic protein secretion in response to intraduodenal fat. This diminished secretion may be due, at least in part, to interruption of the vagal reflexes between the intestine and the pancreas that work independently of cholecystokinin (CCK). In five dogs with chronic pancreatic fistulas, plasma CCK concentrations and pancreatic protein secretion in response to an intestinal stimulant (intraduodenal oleate) and to two exogenous peptides (bombesin and CCK-33) were compared before and after bilateral truncal vagotomy. Vagotomy decreased integrated protein secretion by about 50% in response to intraduodenal oleate. In contrast, protein output in response to parenteral stimuli increased after vagotomy. Integrated output of CCK in response to intraduodenal oleate or to exogenous bombesin or CCK was not significantly affected by vagotomy, but release of pancreatic polypeptide was decreased significantly in response to all stimuli after truncal vagotomy. These data provide evidence that truncal vagotomy decreases pancreatic protein secretion in response to intestinal stimulants by interrupting enteropancreatic reflexes mediated by the vagus, while maintaining normal (or supranormal) sensitivity of the pancreas to endogenous and exogenous CCK.
AB - Truncal vagotomy results in diminisched pancreatic protein secretion in response to intraduodenal fat. This diminished secretion may be due, at least in part, to interruption of the vagal reflexes between the intestine and the pancreas that work independently of cholecystokinin (CCK). In five dogs with chronic pancreatic fistulas, plasma CCK concentrations and pancreatic protein secretion in response to an intestinal stimulant (intraduodenal oleate) and to two exogenous peptides (bombesin and CCK-33) were compared before and after bilateral truncal vagotomy. Vagotomy decreased integrated protein secretion by about 50% in response to intraduodenal oleate. In contrast, protein output in response to parenteral stimuli increased after vagotomy. Integrated output of CCK in response to intraduodenal oleate or to exogenous bombesin or CCK was not significantly affected by vagotomy, but release of pancreatic polypeptide was decreased significantly in response to all stimuli after truncal vagotomy. These data provide evidence that truncal vagotomy decreases pancreatic protein secretion in response to intestinal stimulants by interrupting enteropancreatic reflexes mediated by the vagus, while maintaining normal (or supranormal) sensitivity of the pancreas to endogenous and exogenous CCK.
UR - http://www.scopus.com/inward/record.url?scp=0021879479&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021879479&partnerID=8YFLogxK
U2 - 10.1097/00000658-198507000-00009
DO - 10.1097/00000658-198507000-00009
M3 - Article
C2 - 4015214
AN - SCOPUS:0021879479
VL - 202
SP - 69
EP - 74
JO - Annals of Surgery
JF - Annals of Surgery
SN - 0003-4932
IS - 1
ER -