Experimental hypertension and other responses to 18-hydroxy- deoxycorticosterone treatment in the rat

C. E. Hall, C. E. Gomez-Sanchez, O. B. Holland, D. Nasseth

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Young female unilaterally nephrectomized, salt-loaded, Sprague-Dawley rats were treated with 200 μg or 1 mg 18-hydroxy-deoxycorticosterone-21-acetate (18-OH-DOCA) in oil daily, and a group of kidney-intact animals on a normal salt intake was given 2 mg/day. The hormone was not found to increase saline consumption, increase urinary potassium or kallikrein excretion, or depress serum renin activity or potassium concentration. Slight hypertension did develop at 3 weeks in salt-loaded rats on the lowest dose, but this was neither increased by higher dosage or longer treatment, nor reflected by increased heart or kidney weight. The effect of 40-mg pellet implantation of DOCA and 18-OH-DOCA was then compared in unilaterally nephrectomized, salt-loaded, female Fischer 344 rats. The former caused increased saline consumption, hypertension, hypokalemia, and heart and kidney enlargement, whereas 18-OH-DOCA did not. Thus, the hypertensogenic potency of 18-OH-DOCA is, at best, a reflection of its known, very weak, mineralocorticoid activity.

Original languageEnglish (US)
Pages (from-to)133-140
Number of pages8
JournalEndocrinology
Volume103
Issue number1
StatePublished - 1978

Fingerprint

Desoxycorticosterone Acetate
Desoxycorticosterone
Hypertension
Salts
Kidney
Potassium
Mineralocorticoids
Kallikreins
Hypokalemia
Inbred F344 Rats
Cardiomegaly
Renin
Sprague Dawley Rats
Oils
Hormones
Weights and Measures
hydroxide ion
Serum

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Hall, C. E., Gomez-Sanchez, C. E., Holland, O. B., & Nasseth, D. (1978). Experimental hypertension and other responses to 18-hydroxy- deoxycorticosterone treatment in the rat. Endocrinology, 103(1), 133-140.

Experimental hypertension and other responses to 18-hydroxy- deoxycorticosterone treatment in the rat. / Hall, C. E.; Gomez-Sanchez, C. E.; Holland, O. B.; Nasseth, D.

In: Endocrinology, Vol. 103, No. 1, 1978, p. 133-140.

Research output: Contribution to journalArticle

Hall, CE, Gomez-Sanchez, CE, Holland, OB & Nasseth, D 1978, 'Experimental hypertension and other responses to 18-hydroxy- deoxycorticosterone treatment in the rat', Endocrinology, vol. 103, no. 1, pp. 133-140.
Hall, C. E. ; Gomez-Sanchez, C. E. ; Holland, O. B. ; Nasseth, D. / Experimental hypertension and other responses to 18-hydroxy- deoxycorticosterone treatment in the rat. In: Endocrinology. 1978 ; Vol. 103, No. 1. pp. 133-140.
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