Experimental models for leishmaniasis and for testing anti-leishmanial vaccines

M. Hommel, C. L. Jaffe, B. Travi, G. Milon

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

In public health terms, leishmaniases are diseases of humans and dogs, whereas, in epidemiological terms, Leishmania spp. are considered to represent infections of a wide variety of animals, which represent the natural reservoirs of the various parasite species involved. Humans and dogs (which may be considered secondary or 'accidental' hosts in the leishmanial life-cycle) often exhibit severe clinical signs and symptoms when infected, whereas reservoir hosts generally show a few, minor or no signs. This situation makes the definition of a suitable laboratory model a difficult one, since the various experimental hosts may behave either like a reservoir or an accidental host. This review discusses the concept of animal models for leishmaniases and provides a critical evaluation of the most common experimental models and their respective advantages and disadvantages. In this state-of-the-art review, particular emphasis is given to the value of using mouse, hamster, cotton-rat, dog and primate models, especially in the context of testing potential anti-leishmanial vaccines.

Original languageEnglish (US)
Pages (from-to)55-73
Number of pages19
JournalAnnals of Tropical Medicine and Parasitology
Volume89
Issue numberSUPPL. 1
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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