Experimental models to study molecular mechanisms underlying intestinal inflammation

Charles O. Elson, Y. Cong, S. Brandwein, C. T. Weaver, R. P. McCabe, M. Mähler, J. P. Sundberg, E. H. Leiter

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Experimental animal models, particularly the newer mouse models, have convincingly demonstrated that CD+ T cells play a central role in chronic intestinal inflammation. Such CD4+ effector T cells are induced by the bacterial flora. In at least one model, it is conventional protein antigens that are stimulating these pathogenic T cells. The antigens driving disease seem to be a selective subset of immunodominant proteins, likely derived from a subset of organisms. Multiple genes contribute to colitis susceptibility and a number of these genes are being localized.

Original languageEnglish (US)
Pages (from-to)85-95
Number of pages11
JournalAnnals of the New York Academy of Sciences
Volume859
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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