Experimental myocarditis induced in mice by infection with influenza A 2 virus

M. Sakamoto, Fujio Suzuki, S. Arai, T. Takishima, N. Ishida

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A mouse model was established for the study of acute myocarditis that occurs during influenza infection. Challenge with more than 10 LD 50 of mouse-adapted influenza A 2 virus (H 2N 2) induced myocarditis, macroscopically discernible as white, irregularly shaped lesions which were shown by histological examination to consist of necrotic myofibers surrounded by infiltrating mononuclear inflammatory cells. After challenge with 10 LD 50 of the virus, macroscopic myocarditis was found to advance in a progressive manner up to the 7th day, while the virus titer in the heart reached its peak on the 2nd day and began to decrease on the 5th day of infection. However, development of myocarditis was significantly suppressed in mice which were irradiated with 400 R of X-rays before infection. In addition, myocarditis did not develop in congenitally athymic nude mice. These data indicate that myocarditis was not brought about by viral action directly, but that it was mediated by some function of the host against viral invasion, which was abolished by X-irradiation. The data also suggest that T cells played a key role in the development of myocarditis.

Original languageEnglish (US)
Pages (from-to)173-181
Number of pages9
JournalMicrobiology and Immunology
Volume25
Issue number2
StatePublished - 1981
Externally publishedYes

Fingerprint

Influenza A virus
Myocarditis
Infection
Nude Mice
Viral Load
Human Influenza
X-Rays
Viruses
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Microbiology

Cite this

Sakamoto, M., Suzuki, F., Arai, S., Takishima, T., & Ishida, N. (1981). Experimental myocarditis induced in mice by infection with influenza A 2 virus. Microbiology and Immunology, 25(2), 173-181.

Experimental myocarditis induced in mice by infection with influenza A 2 virus. / Sakamoto, M.; Suzuki, Fujio; Arai, S.; Takishima, T.; Ishida, N.

In: Microbiology and Immunology, Vol. 25, No. 2, 1981, p. 173-181.

Research output: Contribution to journalArticle

Sakamoto, M, Suzuki, F, Arai, S, Takishima, T & Ishida, N 1981, 'Experimental myocarditis induced in mice by infection with influenza A 2 virus', Microbiology and Immunology, vol. 25, no. 2, pp. 173-181.
Sakamoto, M. ; Suzuki, Fujio ; Arai, S. ; Takishima, T. ; Ishida, N. / Experimental myocarditis induced in mice by infection with influenza A 2 virus. In: Microbiology and Immunology. 1981 ; Vol. 25, No. 2. pp. 173-181.
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