Experimental yellow fever virus infection in the golden hamster (Mesocricetus auratus) III. Clinical laboratory values

Elena Sbrana, Shu Yuan Xiao, Vsevolod L. Popov, Patrick C. Newman, Robert B. Tesh

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Using a recently described hamster model of yellow fever (YF), we compared the hematologic and clinical chemistry changes that occur in blood with the histopathologic alternations observed in liver and other organs. Inflammatory foci and necroapoptotic hepatocytes were first observed in the liver three days after YF infection. This was accompanied by a rapid increase in serum transaminase and bilirubin values, elevation of prothrombin times, thrombocytopenia, and leukocytosis. Maximum liver pathology was observed on the sixth and seventh days post-infection; this corresponded to the peak alternations in clinical chemistry and hematologic values. In surviving hamsters, regenerating hepatocytes began to appear on the eighth day post-infection; this was accompanied by a corresponding return to baseline levels of most of the aforementioned clinical laboratory values. The histopathologic and clinical laboratory findings in the hamster model were very similar to those observed in severe human cases of YF. These results provide further validation of the utility of the hamster model for studying the pathogenesis and treatment of YF.

Original languageEnglish (US)
Pages (from-to)1084-1089
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume74
Issue number6
DOIs
StatePublished - Jun 2006

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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