Experimental yellow fever virus infection in the golden hamster (Mesocricetus auratus) III. Clinical laboratory values

Elena Sbrana, Shu Yuan Xiao, Vsevolod Popov, Patrick C. Newman, Robert B. Tesh

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Using a recently described hamster model of yellow fever (YF), we compared the hematologic and clinical chemistry changes that occur in blood with the histopathologic alternations observed in liver and other organs. Inflammatory foci and necroapoptotic hepatocytes were first observed in the liver three days after YF infection. This was accompanied by a rapid increase in serum transaminase and bilirubin values, elevation of prothrombin times, thrombocytopenia, and leukocytosis. Maximum liver pathology was observed on the sixth and seventh days post-infection; this corresponded to the peak alternations in clinical chemistry and hematologic values. In surviving hamsters, regenerating hepatocytes began to appear on the eighth day post-infection; this was accompanied by a corresponding return to baseline levels of most of the aforementioned clinical laboratory values. The histopathologic and clinical laboratory findings in the hamster model were very similar to those observed in severe human cases of YF. These results provide further validation of the utility of the hamster model for studying the pathogenesis and treatment of YF.

Original languageEnglish (US)
Pages (from-to)1084-1089
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume74
Issue number6
StatePublished - Jun 2006

Fingerprint

Yellow fever virus
Yellow Fever
Mesocricetus
Virus Diseases
Cricetinae
Clinical Chemistry
Hepatocytes
Liver
Infection
Prothrombin Time
Leukocytosis
Transaminases
Bilirubin
Thrombocytopenia
Pathology
Serum

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Experimental yellow fever virus infection in the golden hamster (Mesocricetus auratus) III. Clinical laboratory values. / Sbrana, Elena; Xiao, Shu Yuan; Popov, Vsevolod; Newman, Patrick C.; Tesh, Robert B.

In: American Journal of Tropical Medicine and Hygiene, Vol. 74, No. 6, 06.2006, p. 1084-1089.

Research output: Contribution to journalArticle

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