Experimental zika virus infection of neotropical primates

John A. Vanchiere, Julio C. Ruiz, Alan G. Brady, Thomas J. Kuehl, Lawrence E. Williams, Wallace B. Baze, Gregory K. Wilkerson, Pramod N. Nehete, Gloria B. McClure, Donna L. Rogers, Shannan Rossi, Sasha R. Azar, Christopher M. Roundy, Scott Weaver, Nikos Vasilakis, Joe H. Simmons, Christian R. Abee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The establishment of a sylvatic reservoir of Zika virus (ZIKV) in the Americas is dependent on the susceptibility of primates of sufficient population density, the duration and magnitude of viremia, and their exposure to the human mosquito-borne transmission cycle. To assess the susceptibility of squirrel (Saimiri sp.) and owl monkeys (Aotus sp.) to infection, we inoculated four animals of each species with ZIKV from the current epidemic. Viremia in the absence of detectible disease was observed in both species and seroconversion occurred by day 28. ZIKV was detected in the spleen of three owl monkeys: One at 7 days postinoculation (dpi) and two at 14 dpi. This study confirms the susceptibility to ZIKV infection of two Neotropical primate species that live in close proximity to humans in South America, suggesting that they could support awidespread sylvatic ZIKV cycle there. Collectively, establishment of a ZIKV sylvatic transmission cycle in South America would imperil eradication efforts and could provide a mechanism for continued exposure of humans to ZIKV infection and disease.

Original languageEnglish (US)
Pages (from-to)173-177
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume98
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Primates
Aotidae
South America
Viremia
Saimiri
Sciuridae
Population Density
Culicidae
Spleen
Zika Virus Infection
Zika Virus
Infection

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Vanchiere, J. A., Ruiz, J. C., Brady, A. G., Kuehl, T. J., Williams, L. E., Baze, W. B., ... Abee, C. R. (2018). Experimental zika virus infection of neotropical primates. American Journal of Tropical Medicine and Hygiene, 98(1), 173-177. https://doi.org/10.4269/ajtmh.17-0322

Experimental zika virus infection of neotropical primates. / Vanchiere, John A.; Ruiz, Julio C.; Brady, Alan G.; Kuehl, Thomas J.; Williams, Lawrence E.; Baze, Wallace B.; Wilkerson, Gregory K.; Nehete, Pramod N.; McClure, Gloria B.; Rogers, Donna L.; Rossi, Shannan; Azar, Sasha R.; Roundy, Christopher M.; Weaver, Scott; Vasilakis, Nikos; Simmons, Joe H.; Abee, Christian R.

In: American Journal of Tropical Medicine and Hygiene, Vol. 98, No. 1, 01.01.2018, p. 173-177.

Research output: Contribution to journalArticle

Vanchiere, JA, Ruiz, JC, Brady, AG, Kuehl, TJ, Williams, LE, Baze, WB, Wilkerson, GK, Nehete, PN, McClure, GB, Rogers, DL, Rossi, S, Azar, SR, Roundy, CM, Weaver, S, Vasilakis, N, Simmons, JH & Abee, CR 2018, 'Experimental zika virus infection of neotropical primates', American Journal of Tropical Medicine and Hygiene, vol. 98, no. 1, pp. 173-177. https://doi.org/10.4269/ajtmh.17-0322
Vanchiere JA, Ruiz JC, Brady AG, Kuehl TJ, Williams LE, Baze WB et al. Experimental zika virus infection of neotropical primates. American Journal of Tropical Medicine and Hygiene. 2018 Jan 1;98(1):173-177. https://doi.org/10.4269/ajtmh.17-0322
Vanchiere, John A. ; Ruiz, Julio C. ; Brady, Alan G. ; Kuehl, Thomas J. ; Williams, Lawrence E. ; Baze, Wallace B. ; Wilkerson, Gregory K. ; Nehete, Pramod N. ; McClure, Gloria B. ; Rogers, Donna L. ; Rossi, Shannan ; Azar, Sasha R. ; Roundy, Christopher M. ; Weaver, Scott ; Vasilakis, Nikos ; Simmons, Joe H. ; Abee, Christian R. / Experimental zika virus infection of neotropical primates. In: American Journal of Tropical Medicine and Hygiene. 2018 ; Vol. 98, No. 1. pp. 173-177.
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