Exploring Colitis through Dynamic T Cell Adoptive Transfer Models

Wenjing Yang, Yingzi Cong

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Numerous animal models of colitis have provided important insights into the pathogenesis of inflammatory bowel disease (IBD), contributing to a better understanding of the underlying mechanisms for IBD. As aberrant CD4+ T cell responses play a critical role in the pathogenesis and development of IBD, T cell adoptive transfer models of colitis have become a valuable tool in investigating the immunopathogenesis of intestinal inflammation. While the adoptive transfer of CD4+ CD45RBhi T cells into immunedeficient recipient mice was the first discovered and is currently the most widely used model, several variations of the T cell transfer model have also been developed with distinct features. Here, we describe the history, principle, and characteristics of adoptive transfer colitis models and discuss their strengths, limitations, and applications.

Original languageEnglish (US)
Pages (from-to)1673-1680
Number of pages8
JournalInflammatory bowel diseases
Issue number10
StatePublished - Oct 1 2023


  • CBir1
  • CD45RB
  • Th1
  • Th17
  • Treg

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology


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