Exploring kinase inhibitors as therapies for human arenavirus infections

Eric M. Vela, Gavin C. Bowick, Norbert K. Herzog, Judith F. Aronson

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Arenaviruses are rodent-borne RNA viruses, and some have the capacity to cause hemorrhagic fever and death in infected individuals and thus have been identified as a potential bioterrorism threat. Ribavirin and supportive care are currently the approved therapeutic options for individuals suffering from arenavirus-induced hemorrhagic fever. However, new research has suggested that immune plasma treatment or kinase inhibitors may provide a therapeutic option for treating arenavirus infections in humans. This article puts forth a perspective as to the potential use of kinase inhibitors as an antiviral therapeutic for arenavirus infections.

Original languageEnglish (US)
Pages (from-to)243-251
Number of pages9
JournalFuture Virology
Volume3
Issue number3
DOIs
StatePublished - May 2008

Keywords

  • Antiviral therapeutics
  • Arenavirus
  • Hemorrhagic fever
  • Kinase inhibitors
  • Virology

ASJC Scopus subject areas

  • Virology

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