Exploring the molecular mechanism of trimethylamine-N-oxide's ability to counteract the protein denaturing effects of urea

Keyphrases

• Molecular Mechanism 100%
• Urea 100%
• Protein Denaturants 100%
• Trimethylamine N-oxide 100%
• N-methylacetamide 58%
• Hydrogen Bonds (H-bonds) 16%
• Solvation 16%
• Highly Concentrated 16%
• Protein Denaturation 16%
• Urea Solution 16%
• Hydrogen-rich Water 16%
• Denaturation 8%
• Osmolytes 8%
• Structural Properties 8%
• Solute 8%
• Molecular Dynamics Simulation 8%
• Dehydration 8%
• Dynamical Properties 8%
• Hydrogen Bond Network 8%
• Hydrophobic Binding Sites 8%
• Energetic Properties 8%
• Structural Energetics 8%
• Counteracting Effect 8%
• Hydrogen Bond number 8%
• N Reduction 8%
• Peptide Linkage 8%
• Urea-water 8%
• Computer Simulation Technique 8%
• Exposed State 8%
• Reduction by Hydrogen 8%

Biochemistry, Genetics and Molecular Biology

• Trimethylamine N-Oxide 100%
• Solution and Solubility 41%
• Hydrogen Bond 25%
• Solvation 16%
• Protein Denaturation 16%
• Dynamics 8%
• Gene Linkage 8%
• Energy Transfer 8%
• Denaturation 8%