Exposure of resting cd4 t-lymphocytes to HIV-1 upregulates l-selectin, the receptor for homing to lymph nodes, resulting in their sequestration from blood into lymph nodes

L. Wang, C. Robb, M. Cloyd, M. Moslenl

Research output: Contribution to journalArticle

Abstract

In vivo infection with HIV-1 eventually results in gradual depletion of CD4 T-lymphocytes in the blood, while for a certain time period T-lymphocytes increase in the lymph nodes (lymphoadenopathy, LAS). The reason for this phenomenon is not known. We found that exposure of resting T lymphocytes to HIV-1 transiently upregulated expression of cell surface CD62L (Lselectin), the receptor for homing to lymph nodes, which resulted in their enhanced binding (increased -12 fold, p < 0.001) to lymph node high endothelial venules (HEVs) in an imatta homing assay and their sequestration from the blood into lymph nodes following i.v. injection into SCID mice. This suggested that the decrease in numbers of CD4 T-lymphocytes in the blood of HIV-1 -infected subjects may reflect sequestration of abortively infected, resting T lymphocytes into lymph nodes rather than direct virus replication in and killing of these cells.

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number6
StatePublished - 1996

Fingerprint

Lymphocyte Homing Receptors
Selectins
T-cells
Lymphocytes
Human immunodeficiency virus 1
lymph nodes
HIV-1
Blood
Up-Regulation
lymphocytes
T-lymphocytes
Lymph Nodes
T-Lymphocytes
receptors
blood
Cells
SCID Mice
Venules
Virus Replication
virus replication

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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Exposure of resting cd4 t-lymphocytes to HIV-1 upregulates l-selectin, the receptor for homing to lymph nodes, resulting in their sequestration from blood into lymph nodes. / Wang, L.; Robb, C.; Cloyd, M.; Moslenl, M.

In: FASEB Journal, Vol. 10, No. 6, 1996.

Research output: Contribution to journalArticle

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AU - Moslenl, M.

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