Exposure to ethylene glycol monomethyl ether

Clinical and cytogenetic findings

Randa A. El-Zein, Sherif Abdel-Rahman, Debra L. Morris, Marvin S. Legator

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Glycol ethers are known reproductive and developmental toxins in laboratory animals, but little is known about their genotoxic effects in humans. In the current article, the authors tested the hypothesis that human in utero exposure to ethylene glycol monomethyl ether (EGME) is associated with the development of specific congenital anomalies and elevated levels of chromosome aberrations. The authors conducted a clinical and cytogenetic evaluation of 41 offspring of 28 females occupationally exposed to EGME for an average duration of 4.6 yr. Six offspring of 5 women who were occupationally exposed to EGME during pregnancy exhibited characteristic dysmorphic features that were not observed in 35 offspring of 23 women who worked in the same facility, but who were not pregnant at the time of exposure. Persistent cytogenetic damage was observed exclusively in all 6 in-utero-exposed offspring, but not in their 12 match non-in-utero-exposed controls. The study characterizes EGME as a human teratogen, as indicated by the prevalence of characteristic dysmorphic features and persistent cytogenetic damage in individuals exposed in utero to this chemical.

Original languageEnglish (US)
Pages (from-to)371-376
Number of pages6
JournalArchives of Environmental Health
Volume57
Issue number4
StatePublished - Jul 2002

Fingerprint

cytogenetics
Cytogenetics
ether
ethylene
Teratogens
Glycols
Ethers
Laboratory Animals
Chromosomes
Aberrations
damage
Chromosome Aberrations
Animals
pregnancy
toxin
chromosome
Pregnancy
exposure
methyl cellosolve
anomaly

Keywords

  • Chromosome aberration
  • Dysmorphism
  • FISH
  • Glycol ethers
  • Reproductive toxicity

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Exposure to ethylene glycol monomethyl ether : Clinical and cytogenetic findings. / El-Zein, Randa A.; Abdel-Rahman, Sherif; Morris, Debra L.; Legator, Marvin S.

In: Archives of Environmental Health, Vol. 57, No. 4, 07.2002, p. 371-376.

Research output: Contribution to journalArticle

El-Zein, Randa A. ; Abdel-Rahman, Sherif ; Morris, Debra L. ; Legator, Marvin S. / Exposure to ethylene glycol monomethyl ether : Clinical and cytogenetic findings. In: Archives of Environmental Health. 2002 ; Vol. 57, No. 4. pp. 371-376.
@article{1120db8d72734639bd62f1e731ce9a7e,
title = "Exposure to ethylene glycol monomethyl ether: Clinical and cytogenetic findings",
abstract = "Glycol ethers are known reproductive and developmental toxins in laboratory animals, but little is known about their genotoxic effects in humans. In the current article, the authors tested the hypothesis that human in utero exposure to ethylene glycol monomethyl ether (EGME) is associated with the development of specific congenital anomalies and elevated levels of chromosome aberrations. The authors conducted a clinical and cytogenetic evaluation of 41 offspring of 28 females occupationally exposed to EGME for an average duration of 4.6 yr. Six offspring of 5 women who were occupationally exposed to EGME during pregnancy exhibited characteristic dysmorphic features that were not observed in 35 offspring of 23 women who worked in the same facility, but who were not pregnant at the time of exposure. Persistent cytogenetic damage was observed exclusively in all 6 in-utero-exposed offspring, but not in their 12 match non-in-utero-exposed controls. The study characterizes EGME as a human teratogen, as indicated by the prevalence of characteristic dysmorphic features and persistent cytogenetic damage in individuals exposed in utero to this chemical.",
keywords = "Chromosome aberration, Dysmorphism, FISH, Glycol ethers, Reproductive toxicity",
author = "El-Zein, {Randa A.} and Sherif Abdel-Rahman and Morris, {Debra L.} and Legator, {Marvin S.}",
year = "2002",
month = "7",
language = "English (US)",
volume = "57",
pages = "371--376",
journal = "Archives of Environmental and Occupational Health",
issn = "1933-8244",
publisher = "Heldref Publications",
number = "4",

}

TY - JOUR

T1 - Exposure to ethylene glycol monomethyl ether

T2 - Clinical and cytogenetic findings

AU - El-Zein, Randa A.

AU - Abdel-Rahman, Sherif

AU - Morris, Debra L.

AU - Legator, Marvin S.

PY - 2002/7

Y1 - 2002/7

N2 - Glycol ethers are known reproductive and developmental toxins in laboratory animals, but little is known about their genotoxic effects in humans. In the current article, the authors tested the hypothesis that human in utero exposure to ethylene glycol monomethyl ether (EGME) is associated with the development of specific congenital anomalies and elevated levels of chromosome aberrations. The authors conducted a clinical and cytogenetic evaluation of 41 offspring of 28 females occupationally exposed to EGME for an average duration of 4.6 yr. Six offspring of 5 women who were occupationally exposed to EGME during pregnancy exhibited characteristic dysmorphic features that were not observed in 35 offspring of 23 women who worked in the same facility, but who were not pregnant at the time of exposure. Persistent cytogenetic damage was observed exclusively in all 6 in-utero-exposed offspring, but not in their 12 match non-in-utero-exposed controls. The study characterizes EGME as a human teratogen, as indicated by the prevalence of characteristic dysmorphic features and persistent cytogenetic damage in individuals exposed in utero to this chemical.

AB - Glycol ethers are known reproductive and developmental toxins in laboratory animals, but little is known about their genotoxic effects in humans. In the current article, the authors tested the hypothesis that human in utero exposure to ethylene glycol monomethyl ether (EGME) is associated with the development of specific congenital anomalies and elevated levels of chromosome aberrations. The authors conducted a clinical and cytogenetic evaluation of 41 offspring of 28 females occupationally exposed to EGME for an average duration of 4.6 yr. Six offspring of 5 women who were occupationally exposed to EGME during pregnancy exhibited characteristic dysmorphic features that were not observed in 35 offspring of 23 women who worked in the same facility, but who were not pregnant at the time of exposure. Persistent cytogenetic damage was observed exclusively in all 6 in-utero-exposed offspring, but not in their 12 match non-in-utero-exposed controls. The study characterizes EGME as a human teratogen, as indicated by the prevalence of characteristic dysmorphic features and persistent cytogenetic damage in individuals exposed in utero to this chemical.

KW - Chromosome aberration

KW - Dysmorphism

KW - FISH

KW - Glycol ethers

KW - Reproductive toxicity

UR - http://www.scopus.com/inward/record.url?scp=0036629559&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036629559&partnerID=8YFLogxK

M3 - Article

VL - 57

SP - 371

EP - 376

JO - Archives of Environmental and Occupational Health

JF - Archives of Environmental and Occupational Health

SN - 1933-8244

IS - 4

ER -