Exposure to inhomogeneous static magnetic field beneficially affects allergic inflammation in a murine model

Anikó Csillag, Brahma V. Kumar, Krisztina Szabó, Mária Szilasi, Zsuzsa Papp, Magdolna E. Szilasi, Kitti Pázmándi, Istvan Boldogh, Éva Rajnavölgyi, Attila Bácsi, János F. László

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Previous observations suggest that static magnetic field (SMF)-exposure acts on living organisms partly through reactive oxygen species (ROS) reactions. In this study, we aimed to define the impact of SMF-exposure on ragweed pollen extract (RWPE)-induced allergic inflammation closely associated with oxidative stress. Inhomogeneous SMF was generated with an apparatus validated previously providing a peak-to-peak magnetic induction of the dominant SMF component 389 mT by 39 T m-1 lateral gradient in the in vivo and in vitro experiments, and 192 mT by 19 T m-1 in the human study at the 3 mm target distance. Effects of SMF-exposure were studied in a murine model of allergic inflammation and also in human provoked skin allergy.We found that even a single 30-min exposure of mice to SMF immediately following intranasal RWPE challenge significantly lowered the increase in the total antioxidant capacity of the airways and decreased allergic inflammation. Repeated (on 3 consecutive days) or prolonged (60 min) exposure to SMF after RWPE challenge decreased the severity of allergic responses more efficiently than a single 30-min treatment. SMF-exposure did not alter ROS production by RWPE under cell-free conditions, while diminished RWPE-induced increase in the ROS levels in A549 epithelial cells. Results of the human skin prick tests indicated that SMF-exposure had no significant direct effect on provoked mast cell degranulation. The observed beneficial effects of SMF are likely owing to the mobilization of cellular ROS-eliminating mechanisms rather than direct modulation of ROS production by pollen NAD(P)H oxidases.

Original languageEnglish (US)
Article number20140097
JournalJournal of the Royal Society Interface
Volume11
Issue number95
DOIs
StatePublished - Jun 6 2014

Fingerprint

Magnetic Fields
Magnetic fields
Inflammation
Reactive Oxygen Species
Oxygen
Skin
Allergies
Cell Degranulation
Oxidative stress
Electromagnetic induction
NADPH Oxidase
Pollen
Skin Tests
Cell Extracts
Antioxidants
Mast Cells
Hypersensitivity
Oxidative Stress
Epithelial Cells
Modulation

Keywords

  • Allergic inflammation
  • Oxidative stress
  • Pollen
  • Static magnetic field

ASJC Scopus subject areas

  • Biophysics
  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Biomaterials
  • Biochemistry
  • Medicine(all)

Cite this

Csillag, A., Kumar, B. V., Szabó, K., Szilasi, M., Papp, Z., Szilasi, M. E., ... László, J. F. (2014). Exposure to inhomogeneous static magnetic field beneficially affects allergic inflammation in a murine model. Journal of the Royal Society Interface, 11(95), [20140097]. https://doi.org/10.1098/rsif.2014.0097

Exposure to inhomogeneous static magnetic field beneficially affects allergic inflammation in a murine model. / Csillag, Anikó; Kumar, Brahma V.; Szabó, Krisztina; Szilasi, Mária; Papp, Zsuzsa; Szilasi, Magdolna E.; Pázmándi, Kitti; Boldogh, Istvan; Rajnavölgyi, Éva; Bácsi, Attila; László, János F.

In: Journal of the Royal Society Interface, Vol. 11, No. 95, 20140097, 06.06.2014.

Research output: Contribution to journalArticle

Csillag, A, Kumar, BV, Szabó, K, Szilasi, M, Papp, Z, Szilasi, ME, Pázmándi, K, Boldogh, I, Rajnavölgyi, É, Bácsi, A & László, JF 2014, 'Exposure to inhomogeneous static magnetic field beneficially affects allergic inflammation in a murine model', Journal of the Royal Society Interface, vol. 11, no. 95, 20140097. https://doi.org/10.1098/rsif.2014.0097
Csillag, Anikó ; Kumar, Brahma V. ; Szabó, Krisztina ; Szilasi, Mária ; Papp, Zsuzsa ; Szilasi, Magdolna E. ; Pázmándi, Kitti ; Boldogh, Istvan ; Rajnavölgyi, Éva ; Bácsi, Attila ; László, János F. / Exposure to inhomogeneous static magnetic field beneficially affects allergic inflammation in a murine model. In: Journal of the Royal Society Interface. 2014 ; Vol. 11, No. 95.
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