Expression of cell surface friend virus gp70 does not block reinfection by ecotropic murine leukemia viruses

B. Chesebro; J. K. Collins; K. Wehrly; J. Nishio; M. Lloyd

doi:10.1016/0042-6822(81)90094-5

Expression of cell surface friend virus gp70 does not block reinfection by ecotropic murine leukemia viruses

B. Chesebro, J. K. Collins, K. Wehrly, J. Nishio, M. Lloyd

Microbiology And Immunology

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Abstract

The effect of cell surface gp70 expression on reinfection by murine leukemia virus was studied in Friend virus (FV)-induced erythroleukemia cell clones. A clone (2C) which released gp70-positive infectious virions and expressed large amounts of cell surface ecotropic FV gp70 was not superinfectable by ecotropic viruses, whereas another clone (7C) which expressed similar amounts of cell surface FV gp70 but released gp70-deficient virions showed no resistance to superinfection. The lack of interference to superinfection of 7C cells suggested that newly budded gp70-positive virions, rather than cell surface gp70 molecules, were responsible for the interference to superinfection seen in 2C cells which released infectious virus.

Original language	English (US)
Pages (from-to)	125-129
Number of pages	5
Journal	Virology
Volume	115
Issue number	1
DOIs	https://doi.org/10.1016/0042-6822(81)90094-5
State	Published - Nov 1981

ASJC Scopus subject areas

Virology

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title = "Expression of cell surface friend virus gp70 does not block reinfection by ecotropic murine leukemia viruses",

abstract = "The effect of cell surface gp70 expression on reinfection by murine leukemia virus was studied in Friend virus (FV)-induced erythroleukemia cell clones. A clone (2C) which released gp70-positive infectious virions and expressed large amounts of cell surface ecotropic FV gp70 was not superinfectable by ecotropic viruses, whereas another clone (7C) which expressed similar amounts of cell surface FV gp70 but released gp70-deficient virions showed no resistance to superinfection. The lack of interference to superinfection of 7C cells suggested that newly budded gp70-positive virions, rather than cell surface gp70 molecules, were responsible for the interference to superinfection seen in 2C cells which released infectious virus.",

author = "B. Chesebro and Collins, {J. K.} and K. Wehrly and J. Nishio and M. Lloyd",

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T1 - Expression of cell surface friend virus gp70 does not block reinfection by ecotropic murine leukemia viruses

AU - Chesebro, B.

AU - Collins, J. K.

AU - Wehrly, K.

AU - Nishio, J.

AU - Lloyd, M.

PY - 1981/11

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AB - The effect of cell surface gp70 expression on reinfection by murine leukemia virus was studied in Friend virus (FV)-induced erythroleukemia cell clones. A clone (2C) which released gp70-positive infectious virions and expressed large amounts of cell surface ecotropic FV gp70 was not superinfectable by ecotropic viruses, whereas another clone (7C) which expressed similar amounts of cell surface FV gp70 but released gp70-deficient virions showed no resistance to superinfection. The lack of interference to superinfection of 7C cells suggested that newly budded gp70-positive virions, rather than cell surface gp70 molecules, were responsible for the interference to superinfection seen in 2C cells which released infectious virus.

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Expression of cell surface friend virus gp70 does not block reinfection by ecotropic murine leukemia viruses

Abstract

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