Expression of CX3CL1 (fractalkine) in mice with endothelial-target rickettsial infection of the spotted-fever group

Gustavo Valbuena, David Walker

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Fractalkine (CX3CL1) is a chemokine expressed mainly by endothelial cells, which are the major cellular targets of rickettsiae. We used immunohistochemistry to investigate the normal expression of CX3CL1 in mice and the kinetics of expression of this chemokine throughout the course of lethal and sublethal rickettsial infections in a mouse model of spotted-fever group rickettsioses. The peak of expression of fractalkine on day 3 of infection coincided with the time of infiltration of macrophages into infected tissues and preceded the peak of rickettsial content in tissues.

Original languageEnglish (US)
Pages (from-to)21-27
Number of pages7
JournalVirchows Archiv
Volume446
Issue number1
DOIs
StatePublished - Jan 2005

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Chemokine CX3CL1
Chemokines
Fever
Rickettsia
Infection
Endothelial Cells
Immunohistochemistry
Macrophages

Keywords

  • CX3CL1
  • Fractalkine
  • Immunity
  • Rickettsia
  • Spotted fever mouse

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Expression of CX3CL1 (fractalkine) in mice with endothelial-target rickettsial infection of the spotted-fever group. / Valbuena, Gustavo; Walker, David.

In: Virchows Archiv, Vol. 446, No. 1, 01.2005, p. 21-27.

Research output: Contribution to journalArticle

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