Expression of CX3CL1 (fractalkine) in mice with endothelial-target rickettsial infection of the spotted-fever group

Gustavo Valbuena, David H. Walker

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Fractalkine (CX3CL1) is a chemokine expressed mainly by endothelial cells, which are the major cellular targets of rickettsiae. We used immunohistochemistry to investigate the normal expression of CX3CL1 in mice and the kinetics of expression of this chemokine throughout the course of lethal and sublethal rickettsial infections in a mouse model of spotted-fever group rickettsioses. The peak of expression of fractalkine on day 3 of infection coincided with the time of infiltration of macrophages into infected tissues and preceded the peak of rickettsial content in tissues.

Original languageEnglish (US)
Pages (from-to)21-27
Number of pages7
JournalVirchows Archiv
Volume446
Issue number1
DOIs
StatePublished - Jan 1 2005

Keywords

  • CX3CL1
  • Fractalkine
  • Immunity
  • Rickettsia
  • Spotted fever mouse

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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