Expression of CX3CL1 (fractalkine) in mice with endothelial-target rickettsial infection of the spotted-fever group

Gustavo Valbuena; David H. Walker

doi:10.1007/s00428-004-1120-3

Expression of CX3CL1 (fractalkine) in mice with endothelial-target rickettsial infection of the spotted-fever group

Gustavo Valbuena, David H. Walker

Pathology

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Fractalkine (CX3CL1) is a chemokine expressed mainly by endothelial cells, which are the major cellular targets of rickettsiae. We used immunohistochemistry to investigate the normal expression of CX3CL1 in mice and the kinetics of expression of this chemokine throughout the course of lethal and sublethal rickettsial infections in a mouse model of spotted-fever group rickettsioses. The peak of expression of fractalkine on day 3 of infection coincided with the time of infiltration of macrophages into infected tissues and preceded the peak of rickettsial content in tissues.

Original language	English (US)
Pages (from-to)	21-27
Number of pages	7
Journal	Virchows Archiv
Volume	446
Issue number	1
DOIs	https://doi.org/10.1007/s00428-004-1120-3
State	Published - Jan 2005

Keywords

CX3CL1
Fractalkine
Immunity
Rickettsia
Spotted fever mouse

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Biology
Cell Biology

Access to Document

10.1007/s00428-004-1120-3

Cite this

@article{f1214dbddfec481caf765ad9f4c032f2,

title = "Expression of CX3CL1 (fractalkine) in mice with endothelial-target rickettsial infection of the spotted-fever group",

abstract = "Fractalkine (CX3CL1) is a chemokine expressed mainly by endothelial cells, which are the major cellular targets of rickettsiae. We used immunohistochemistry to investigate the normal expression of CX3CL1 in mice and the kinetics of expression of this chemokine throughout the course of lethal and sublethal rickettsial infections in a mouse model of spotted-fever group rickettsioses. The peak of expression of fractalkine on day 3 of infection coincided with the time of infiltration of macrophages into infected tissues and preceded the peak of rickettsial content in tissues.",

keywords = "CX3CL1, Fractalkine, Immunity, Rickettsia, Spotted fever mouse",

author = "Gustavo Valbuena and Walker, {David H.}",

note = "Funding Information: Acknowledgements Sources of support: NIH grant RO1 AI21242 to D.H. Walker, College of American Pathologists Foundation Scholars Research Fellowship and James W. McLaughlin Predoctoral Fellowship awarded to G. Valbuena. We thank Susan Butler for her assistance with preparation of the manuscript.",

year = "2005",

month = jan,

doi = "10.1007/s00428-004-1120-3",

language = "English (US)",

volume = "446",

pages = "21--27",

journal = "Virchows Archiv",

issn = "0945-6317",

publisher = "Springer Verlag",

number = "1",

}

TY - JOUR

T1 - Expression of CX3CL1 (fractalkine) in mice with endothelial-target rickettsial infection of the spotted-fever group

AU - Valbuena, Gustavo

AU - Walker, David H.

N1 - Funding Information: Acknowledgements Sources of support: NIH grant RO1 AI21242 to D.H. Walker, College of American Pathologists Foundation Scholars Research Fellowship and James W. McLaughlin Predoctoral Fellowship awarded to G. Valbuena. We thank Susan Butler for her assistance with preparation of the manuscript.

PY - 2005/1

Y1 - 2005/1

N2 - Fractalkine (CX3CL1) is a chemokine expressed mainly by endothelial cells, which are the major cellular targets of rickettsiae. We used immunohistochemistry to investigate the normal expression of CX3CL1 in mice and the kinetics of expression of this chemokine throughout the course of lethal and sublethal rickettsial infections in a mouse model of spotted-fever group rickettsioses. The peak of expression of fractalkine on day 3 of infection coincided with the time of infiltration of macrophages into infected tissues and preceded the peak of rickettsial content in tissues.

AB - Fractalkine (CX3CL1) is a chemokine expressed mainly by endothelial cells, which are the major cellular targets of rickettsiae. We used immunohistochemistry to investigate the normal expression of CX3CL1 in mice and the kinetics of expression of this chemokine throughout the course of lethal and sublethal rickettsial infections in a mouse model of spotted-fever group rickettsioses. The peak of expression of fractalkine on day 3 of infection coincided with the time of infiltration of macrophages into infected tissues and preceded the peak of rickettsial content in tissues.

KW - CX3CL1

KW - Fractalkine

KW - Immunity

KW - Rickettsia

KW - Spotted fever mouse

UR - http://www.scopus.com/inward/record.url?scp=13144258770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13144258770&partnerID=8YFLogxK

U2 - 10.1007/s00428-004-1120-3

DO - 10.1007/s00428-004-1120-3

M3 - Article

C2 - 15480764

AN - SCOPUS:13144258770

SN - 0945-6317

VL - 446

SP - 21

EP - 27

JO - Virchows Archiv

JF - Virchows Archiv

IS - 1

ER -

Expression of CX3CL1 (fractalkine) in mice with endothelial-target rickettsial infection of the spotted-fever group

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this