Expression of HERV-K correlates with status of MEKERK and p16INK4ACDK4 pathways in melanoma cells

Zhongwu Li, Tao Sheng, Xiaohua Wan, Tianshuang Liu, Hai Wu, Jianli Dong

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The dysregulated ERK and RB pathways often coexist in melanoma cells. The K-type human endogenous retrovirus (HERV-K) is implicated in melanomagenesis. Some of the phenotypes that are modified by HERV-K (e.g., changes in cell shape, melanin production, and anchorage-dependent growth) overlap with those that are regulated by ERK and RB pathways. As ERK signaling can regulate retroviruses, we hypothesized that HERV-K expression is controlled by ERKRB pathways. We found that the levels of HERV-K GAG and EVE correlated with the activation of ERK and loss of p16INK4A and that inhibition of MEK or CDK4, especially in combination, reduced HERV-K EVE in melanoma cells.

Original languageEnglish (US)
Pages (from-to)1031-1037
Number of pages7
JournalCancer Investigation
Volume28
Issue number10
DOIs
StatePublished - Nov 2010

Fingerprint

Endogenous Retroviruses
Melanoma
MAP Kinase Signaling System
Cell Shape
Melanins
Mitogen-Activated Protein Kinase Kinases
Retroviridae
Phenotype
Growth

Keywords

  • HERV-K
  • MEKERK
  • Melanoma
  • p16INK4ACDK4

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Expression of HERV-K correlates with status of MEKERK and p16INK4ACDK4 pathways in melanoma cells. / Li, Zhongwu; Sheng, Tao; Wan, Xiaohua; Liu, Tianshuang; Wu, Hai; Dong, Jianli.

In: Cancer Investigation, Vol. 28, No. 10, 11.2010, p. 1031-1037.

Research output: Contribution to journalArticle

Li, Zhongwu ; Sheng, Tao ; Wan, Xiaohua ; Liu, Tianshuang ; Wu, Hai ; Dong, Jianli. / Expression of HERV-K correlates with status of MEKERK and p16INK4ACDK4 pathways in melanoma cells. In: Cancer Investigation. 2010 ; Vol. 28, No. 10. pp. 1031-1037.
@article{6992aef42d584d9b9d6942413a699a53,
title = "Expression of HERV-K correlates with status of MEKERK and p16INK4ACDK4 pathways in melanoma cells",
abstract = "The dysregulated ERK and RB pathways often coexist in melanoma cells. The K-type human endogenous retrovirus (HERV-K) is implicated in melanomagenesis. Some of the phenotypes that are modified by HERV-K (e.g., changes in cell shape, melanin production, and anchorage-dependent growth) overlap with those that are regulated by ERK and RB pathways. As ERK signaling can regulate retroviruses, we hypothesized that HERV-K expression is controlled by ERKRB pathways. We found that the levels of HERV-K GAG and EVE correlated with the activation of ERK and loss of p16INK4A and that inhibition of MEK or CDK4, especially in combination, reduced HERV-K EVE in melanoma cells.",
keywords = "HERV-K, MEKERK, Melanoma, p16INK4ACDK4",
author = "Zhongwu Li and Tao Sheng and Xiaohua Wan and Tianshuang Liu and Hai Wu and Jianli Dong",
year = "2010",
month = "11",
doi = "10.3109/07357907.2010.512604",
language = "English (US)",
volume = "28",
pages = "1031--1037",
journal = "Cancer Investigation",
issn = "0735-7907",
publisher = "Informa Healthcare",
number = "10",

}

TY - JOUR

T1 - Expression of HERV-K correlates with status of MEKERK and p16INK4ACDK4 pathways in melanoma cells

AU - Li, Zhongwu

AU - Sheng, Tao

AU - Wan, Xiaohua

AU - Liu, Tianshuang

AU - Wu, Hai

AU - Dong, Jianli

PY - 2010/11

Y1 - 2010/11

N2 - The dysregulated ERK and RB pathways often coexist in melanoma cells. The K-type human endogenous retrovirus (HERV-K) is implicated in melanomagenesis. Some of the phenotypes that are modified by HERV-K (e.g., changes in cell shape, melanin production, and anchorage-dependent growth) overlap with those that are regulated by ERK and RB pathways. As ERK signaling can regulate retroviruses, we hypothesized that HERV-K expression is controlled by ERKRB pathways. We found that the levels of HERV-K GAG and EVE correlated with the activation of ERK and loss of p16INK4A and that inhibition of MEK or CDK4, especially in combination, reduced HERV-K EVE in melanoma cells.

AB - The dysregulated ERK and RB pathways often coexist in melanoma cells. The K-type human endogenous retrovirus (HERV-K) is implicated in melanomagenesis. Some of the phenotypes that are modified by HERV-K (e.g., changes in cell shape, melanin production, and anchorage-dependent growth) overlap with those that are regulated by ERK and RB pathways. As ERK signaling can regulate retroviruses, we hypothesized that HERV-K expression is controlled by ERKRB pathways. We found that the levels of HERV-K GAG and EVE correlated with the activation of ERK and loss of p16INK4A and that inhibition of MEK or CDK4, especially in combination, reduced HERV-K EVE in melanoma cells.

KW - HERV-K

KW - MEKERK

KW - Melanoma

KW - p16INK4ACDK4

UR - http://www.scopus.com/inward/record.url?scp=78649300911&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649300911&partnerID=8YFLogxK

U2 - 10.3109/07357907.2010.512604

DO - 10.3109/07357907.2010.512604

M3 - Article

VL - 28

SP - 1031

EP - 1037

JO - Cancer Investigation

JF - Cancer Investigation

SN - 0735-7907

IS - 10

ER -