Expression of HERV-K correlates with status of MEKERK and p16INK4ACDK4 pathways in melanoma cells

Zhongwu Li, Tao Sheng, Xiaohua Wan, Tianshuang Liu, Hai Wu, Jianli Dong

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The dysregulated ERK and RB pathways often coexist in melanoma cells. The K-type human endogenous retrovirus (HERV-K) is implicated in melanomagenesis. Some of the phenotypes that are modified by HERV-K (e.g., changes in cell shape, melanin production, and anchorage-dependent growth) overlap with those that are regulated by ERK and RB pathways. As ERK signaling can regulate retroviruses, we hypothesized that HERV-K expression is controlled by ERKRB pathways. We found that the levels of HERV-K GAG and EVE correlated with the activation of ERK and loss of p16INK4A and that inhibition of MEK or CDK4, especially in combination, reduced HERV-K EVE in melanoma cells.

Original languageEnglish (US)
Pages (from-to)1031-1037
Number of pages7
JournalCancer Investigation
Volume28
Issue number10
DOIs
StatePublished - Nov 1 2010

Keywords

  • HERV-K
  • MEKERK
  • Melanoma
  • p16INK4ACDK4

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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