Expression of immunomodulating molecules by recombinant viruses

Can the immunogenicity of live virus vaccines be improved?

Alexander Bukreyev, Igor M. Belyakov

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Several obstacles exist for the development and use of live attenuated vaccines, including difficulty in achieving a proper balance between attenuation of viral replication and immunogenicity; inducing a strong T-helper 1 response in early life when the immune system is T helper 2 biased and immunization is sometimes associated with immunopathology and the immunosuppressive effect of maternal antibodies in infants. For some viral infections, the immune response to natural infection does not confer solid protection, complicating the task of vaccine development. The development of methods for generation of recombinant viruses provided new opportunities for improving the immunogenicity of live virus vaccine candidates, including the construction of viruses that express cytokines or other immunomodulating molecules. Depending on the choice of immunomodulating molecule, various stages of the immune response can be affected, such as antigen presentation or T-cell proliferation and differentiation. In addition to using the approach for development of viral live attenuated vaccines, it is currently being explored for the development of antitumor vaccines. For this type of vaccine, expression of tumor antigens and one or more immunomodulating molecules by one or several recombinant viruses has been proposed.

Original languageEnglish (US)
Pages (from-to)233-245
Number of pages13
JournalExpert Review of Vaccines
Volume1
Issue number2
DOIs
StatePublished - Aug 2002
Externally publishedYes

Fingerprint

Vaccines
Viruses
Attenuated Vaccines
Antigen Presentation
Neoplasm Antigens
Virus Diseases
Immunosuppressive Agents
Cell Differentiation
Immune System
Immunization
Mothers
Cell Proliferation
Cytokines
T-Lymphocytes
Antibodies
Infection

Keywords

  • Antibodies
  • Chemokines
  • Cytokines
  • Cytotoxic T-lymphocyte
  • Immunity
  • Infectious diseases
  • Vaccines
  • Viruses

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Expression of immunomodulating molecules by recombinant viruses : Can the immunogenicity of live virus vaccines be improved? / Bukreyev, Alexander; Belyakov, Igor M.

In: Expert Review of Vaccines, Vol. 1, No. 2, 08.2002, p. 233-245.

Research output: Contribution to journalArticle

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