Expression of nerve growth factor receptors by human peripheral blood mononuclear cells

B. Morgan, L. W. Thorpe, D. Marchetti, J. R. Perez-Polo

    Research output: Contribution to journalArticle

    35 Citations (Scopus)

    Abstract

    In the rat, nerve growth factor (NGF) has been shown to affect immune reactivity by binding to cell surface receptors on a subpopulation of splenic mononuclear cells. This binding occurs in a specific and saturable fashion to what appear to be low-affinity (type II) NGF receptors (NGFR). Immunofluorescence studies here showed that NGFR are also present on a proportion of human peripheral blood mononuclear cells (PBMC). Equilibrium binding studies demonstrated that the binding of NGF to its receptors on PBMC occurs with a single equilibrium binding constant (mean) of 2.11 x 10-9 M. The number of receptors per cell was determined to be approximately 6.94 x 103 receptors/cell. These results would suggest a role for NGF in the regulation of immune function in man, as well as in animals.

    Original languageEnglish (US)
    Pages (from-to)41-45
    Number of pages5
    JournalJournal of Neuroscience Research
    Volume23
    Issue number1
    StatePublished - 1989

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    Nerve Growth Factor Receptors
    Nerve Growth Factor
    Blood Cells
    Nerve Growth Factor Receptor
    Cell Surface Receptors
    Fluorescent Antibody Technique

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Morgan, B., Thorpe, L. W., Marchetti, D., & Perez-Polo, J. R. (1989). Expression of nerve growth factor receptors by human peripheral blood mononuclear cells. Journal of Neuroscience Research, 23(1), 41-45.

    Expression of nerve growth factor receptors by human peripheral blood mononuclear cells. / Morgan, B.; Thorpe, L. W.; Marchetti, D.; Perez-Polo, J. R.

    In: Journal of Neuroscience Research, Vol. 23, No. 1, 1989, p. 41-45.

    Research output: Contribution to journalArticle

    Morgan, B, Thorpe, LW, Marchetti, D & Perez-Polo, JR 1989, 'Expression of nerve growth factor receptors by human peripheral blood mononuclear cells', Journal of Neuroscience Research, vol. 23, no. 1, pp. 41-45.
    Morgan, B. ; Thorpe, L. W. ; Marchetti, D. ; Perez-Polo, J. R. / Expression of nerve growth factor receptors by human peripheral blood mononuclear cells. In: Journal of Neuroscience Research. 1989 ; Vol. 23, No. 1. pp. 41-45.
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