Expression of p75(NGFR) in the olfactory system following peripheral deafferentation

C. P. Turner, J. R. Perez-Polo

    Research output: Contribution to journalArticle

    28 Citations (Scopus)

    Abstract

    Following chemically induced peripheral deafferentation of the main olfactory bulb, expression of the low affinity receptor for neurotrophins, p75(NGFR), was monitored immunohistochemically using monoclonal antibody MAb192. In control animals, p75(NGFR) expression was localized to the glomerular layer of the main olfactory bulb and deepest one third of the olfactory neuroepithelium. Peripheral lesioning dramatically reduced expression of glomerular p75(NGFR) while inducing expression of p75(NGFR) in the olfactory nerve layer. Expression of p75(NGFR) in the lesioned neuroepithelium was disorganized compared with controls. These observations demonstrate that the maintenance of the peripheral input from the neuroepithelium is critical to expression of p75(NGFR) in the main olfactory bulb.

    Original languageEnglish (US)
    Pages (from-to)1023-1026
    Number of pages4
    JournalNeuroReport
    Volume4
    Issue number8
    StatePublished - 1993

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    Olfactory Bulb
    Olfactory Nerve
    Nerve Growth Factor Receptor
    Monoclonal Antibodies
    Maintenance

    Keywords

    • lesion
    • MAb192
    • nerve growth factor receptor
    • olfactory
    • rat
    • regeneration

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Turner, C. P., & Perez-Polo, J. R. (1993). Expression of p75(NGFR) in the olfactory system following peripheral deafferentation. NeuroReport, 4(8), 1023-1026.

    Expression of p75(NGFR) in the olfactory system following peripheral deafferentation. / Turner, C. P.; Perez-Polo, J. R.

    In: NeuroReport, Vol. 4, No. 8, 1993, p. 1023-1026.

    Research output: Contribution to journalArticle

    Turner, CP & Perez-Polo, JR 1993, 'Expression of p75(NGFR) in the olfactory system following peripheral deafferentation', NeuroReport, vol. 4, no. 8, pp. 1023-1026.
    Turner, C. P. ; Perez-Polo, J. R. / Expression of p75(NGFR) in the olfactory system following peripheral deafferentation. In: NeuroReport. 1993 ; Vol. 4, No. 8. pp. 1023-1026.
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