Abstract
Following chemically induced peripheral deafferentation of the main olfactory bulb, expression of the low affinity receptor for neurotrophins, p75(NGFR), was monitored immunohistochemically using monoclonal antibody MAb192. In control animals, p75(NGFR) expression was localized to the glomerular layer of the main olfactory bulb and deepest one third of the olfactory neuroepithelium. Peripheral lesioning dramatically reduced expression of glomerular p75(NGFR) while inducing expression of p75(NGFR) in the olfactory nerve layer. Expression of p75(NGFR) in the lesioned neuroepithelium was disorganized compared with controls. These observations demonstrate that the maintenance of the peripheral input from the neuroepithelium is critical to expression of p75(NGFR) in the main olfactory bulb.
Original language | English (US) |
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Pages (from-to) | 1023-1026 |
Number of pages | 4 |
Journal | NeuroReport |
Volume | 4 |
Issue number | 8 |
State | Published - 1993 |
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Keywords
- lesion
- MAb192
- nerve growth factor receptor
- olfactory
- rat
- regeneration
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Expression of p75(NGFR) in the olfactory system following peripheral deafferentation. / Turner, C. P.; Perez-Polo, J. R.
In: NeuroReport, Vol. 4, No. 8, 1993, p. 1023-1026.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of p75(NGFR) in the olfactory system following peripheral deafferentation
AU - Turner, C. P.
AU - Perez-Polo, J. R.
PY - 1993
Y1 - 1993
N2 - Following chemically induced peripheral deafferentation of the main olfactory bulb, expression of the low affinity receptor for neurotrophins, p75(NGFR), was monitored immunohistochemically using monoclonal antibody MAb192. In control animals, p75(NGFR) expression was localized to the glomerular layer of the main olfactory bulb and deepest one third of the olfactory neuroepithelium. Peripheral lesioning dramatically reduced expression of glomerular p75(NGFR) while inducing expression of p75(NGFR) in the olfactory nerve layer. Expression of p75(NGFR) in the lesioned neuroepithelium was disorganized compared with controls. These observations demonstrate that the maintenance of the peripheral input from the neuroepithelium is critical to expression of p75(NGFR) in the main olfactory bulb.
AB - Following chemically induced peripheral deafferentation of the main olfactory bulb, expression of the low affinity receptor for neurotrophins, p75(NGFR), was monitored immunohistochemically using monoclonal antibody MAb192. In control animals, p75(NGFR) expression was localized to the glomerular layer of the main olfactory bulb and deepest one third of the olfactory neuroepithelium. Peripheral lesioning dramatically reduced expression of glomerular p75(NGFR) while inducing expression of p75(NGFR) in the olfactory nerve layer. Expression of p75(NGFR) in the lesioned neuroepithelium was disorganized compared with controls. These observations demonstrate that the maintenance of the peripheral input from the neuroepithelium is critical to expression of p75(NGFR) in the main olfactory bulb.
KW - lesion
KW - MAb192
KW - nerve growth factor receptor
KW - olfactory
KW - rat
KW - regeneration
UR - http://www.scopus.com/inward/record.url?scp=0027338343&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027338343&partnerID=8YFLogxK
M3 - Article
C2 - 8241456
AN - SCOPUS:0027338343
VL - 4
SP - 1023
EP - 1026
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 8
ER -