Expression of p75NGFR in the olfactory system following peripheral deafferentation

Christopher P. Turner, J. Regino Perez-Polo

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Following chemically induced peripheral deafferentation of the main olfactory bulb, expression of the low affinity receptor for neurotrophins, p75NGFR, was monitored immunohistochemically using monoclonal antibody MAbl92. In control animals, p75NGFR expression was localized to the glomerular layer of the main olfactory bulb and deepest one third of the olfactory neuroepithelium. Peripheral lesioning dramatically reduced expression of glomerular p75NGFR while inducing expression of p75NGFR in the olfactory nerve layer. Expression of p75NGFR in the lesioned neuroepithelium was disorganized compared with controls. These observations demonstrate that the maintenance of the peripheral input from the neuroepithelium is critical to expression of p75NGFR in the main olfactory bulb.

Original languageEnglish (US)
Pages (from-to)1023-1026
Number of pages4
Issue number8
StatePublished - Aug 1993
Externally publishedYes


  • Lesion
  • MAb192
  • Nerve growth factor receptor
  • Olfactory
  • Rat
  • Regeneration

ASJC Scopus subject areas

  • Neuroscience(all)


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