Expression of p75NGFR in the olfactory system following peripheral deafferentation

Christopher P. Turner, J. Regino Perez-Polo

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    28 Scopus citations

    Abstract

    Following chemically induced peripheral deafferentation of the main olfactory bulb, expression of the low affinity receptor for neurotrophins, p75NGFR, was monitored immunohistochemically using monoclonal antibody MAbl92. In control animals, p75NGFR expression was localized to the glomerular layer of the main olfactory bulb and deepest one third of the olfactory neuroepithelium. Peripheral lesioning dramatically reduced expression of glomerular p75NGFR while inducing expression of p75NGFR in the olfactory nerve layer. Expression of p75NGFR in the lesioned neuroepithelium was disorganized compared with controls. These observations demonstrate that the maintenance of the peripheral input from the neuroepithelium is critical to expression of p75NGFR in the main olfactory bulb.

    Original languageEnglish (US)
    Pages (from-to)1023-1026
    Number of pages4
    JournalNeuroReport
    Volume4
    Issue number8
    DOIs
    StatePublished - Aug 1993

    Keywords

    • Lesion
    • MAb192
    • Nerve growth factor receptor
    • Olfactory
    • Rat
    • Regeneration

    ASJC Scopus subject areas

    • Neuroscience(all)

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