Expression of RNA CCUG repeats dysregulates translation and degradation of proteins in myotonic dystrophy 2 patients

Keyphrases

• Protein Degradation 100%
• RNA-binding Protein 100%
• Triplet Repeats 100%
• Myotonic Dystrophy Type 2 100%
• Biological Function 66%
• Overexpression 33%
• Mouse Model 33%
• Protein Complex 33%
• Protein Turnover 33%
• Major Components 33%
• Myoblast 33%
• Protein Translation 33%
• Catalytic Core 33%
• EIF2 33%
• Short-lived Protein 33%
• C2C12 Myoblasts 33%
• Multisystem 33%
• Human Myoblasts 33%
• Skeletal Disorders 33%
• Core Complex 33%
• 20S Proteasome 33%
• Translation Initiation Factor eIF2 33%
• Tetranucleotide 33%
• CGG Repeat 33%

Biochemistry, Genetics and Molecular Biology

• RNA 100%
• Proteasome 100%
• RNA-binding Protein 100%
• Synapsin I 100%
• Biological Functions 66%
• Protein Degradation 66%
• Transcription 33%
• Mouse Model 33%
• Protein Catabolism 33%
• Skeletal Muscle 33%
• C2C12 33%
• Translation (Protein Synthesis) 33%
• Initiation Factor 33%
• Multiprotein Complex 33%