Expression of the low affinity neurotrophin receptor, p75(NGFR), in the rat forebrain, following unilateral bulbectomy

Christopher P. Turner, J. Regino Perez-Polo

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    Abstract

    It has been hypothesized that the main olfactory bulb, with its relatively rich source of neurotrophins, may provide trophic support for neurons that project to the bulb. We monitored expression of the common, low affinity receptor for neurotrophins, p75(NGFR), in the olfactory bulb and basal forebrain of unilaterally bulbectomized and sham-treated rats, 1-16 weeks post-surgery, using the monoclonal antibody MAb192. An induction of p75(NGFR)-immunoreactivity was observed in both the glomerular and olfactory nerve layers of the right, contralateral main olfactory bulb of lesioned animals. The naturally occurring regeneration taking place in the olfactory neuroepithelium is known to be altered by olfactory bulbectomy, with subsequent changes in the sensory input to the remaining bulb. These changes in expression of p75(NGFR) in the olfactory bulb support the hypothesis we have developed in previous papers, that changes in the extent of the peripheral input from the olfactory neuroepithelium to the main olfactory bulb regulate p75(NGFR) expression in both the glomerular and the olfactory nerve layers. Expression of p75(NGFR) in the basal forebrain of bulbectomized animals was found to be no different than sham-treated controls and does not support the hypothesis that the olfactory bulb provides trophic support to this region of the central nervous system.

    Original languageEnglish (US)
    Pages (from-to)527-538
    Number of pages12
    JournalInternational Journal of Developmental Neuroscience
    Volume16
    Issue number6
    DOIs
    StatePublished - Oct 1 1998

    Fingerprint

    Nerve Growth Factor Receptor
    Olfactory Bulb
    Prosencephalon
    Olfactory Nerve
    Nerve Growth Factors
    Regeneration
    Central Nervous System
    Monoclonal Antibodies
    Neurons

    Keywords

    • Lesion
    • Nerve growth factor
    • Olfactory
    • Regeneration

    ASJC Scopus subject areas

    • Developmental Biology
    • Developmental Neuroscience

    Cite this

    Expression of the low affinity neurotrophin receptor, p75(NGFR), in the rat forebrain, following unilateral bulbectomy. / Turner, Christopher P.; Perez-Polo, J. Regino.

    In: International Journal of Developmental Neuroscience, Vol. 16, No. 6, 01.10.1998, p. 527-538.

    Research output: Contribution to journalArticle

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