TY - JOUR
T1 - Expression of the low affinity neurotrophin receptor, p75(NGFR), in the rat forebrain, following unilateral bulbectomy
AU - Turner, Christopher P.
AU - Perez-Polo, J. Regino
N1 - Funding Information:
Supported in part by NINDS-NS 18708.
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1998/10/1
Y1 - 1998/10/1
N2 - It has been hypothesized that the main olfactory bulb, with its relatively rich source of neurotrophins, may provide trophic support for neurons that project to the bulb. We monitored expression of the common, low affinity receptor for neurotrophins, p75(NGFR), in the olfactory bulb and basal forebrain of unilaterally bulbectomized and sham-treated rats, 1-16 weeks post-surgery, using the monoclonal antibody MAb192. An induction of p75(NGFR)-immunoreactivity was observed in both the glomerular and olfactory nerve layers of the right, contralateral main olfactory bulb of lesioned animals. The naturally occurring regeneration taking place in the olfactory neuroepithelium is known to be altered by olfactory bulbectomy, with subsequent changes in the sensory input to the remaining bulb. These changes in expression of p75(NGFR) in the olfactory bulb support the hypothesis we have developed in previous papers, that changes in the extent of the peripheral input from the olfactory neuroepithelium to the main olfactory bulb regulate p75(NGFR) expression in both the glomerular and the olfactory nerve layers. Expression of p75(NGFR) in the basal forebrain of bulbectomized animals was found to be no different than sham-treated controls and does not support the hypothesis that the olfactory bulb provides trophic support to this region of the central nervous system.
AB - It has been hypothesized that the main olfactory bulb, with its relatively rich source of neurotrophins, may provide trophic support for neurons that project to the bulb. We monitored expression of the common, low affinity receptor for neurotrophins, p75(NGFR), in the olfactory bulb and basal forebrain of unilaterally bulbectomized and sham-treated rats, 1-16 weeks post-surgery, using the monoclonal antibody MAb192. An induction of p75(NGFR)-immunoreactivity was observed in both the glomerular and olfactory nerve layers of the right, contralateral main olfactory bulb of lesioned animals. The naturally occurring regeneration taking place in the olfactory neuroepithelium is known to be altered by olfactory bulbectomy, with subsequent changes in the sensory input to the remaining bulb. These changes in expression of p75(NGFR) in the olfactory bulb support the hypothesis we have developed in previous papers, that changes in the extent of the peripheral input from the olfactory neuroepithelium to the main olfactory bulb regulate p75(NGFR) expression in both the glomerular and the olfactory nerve layers. Expression of p75(NGFR) in the basal forebrain of bulbectomized animals was found to be no different than sham-treated controls and does not support the hypothesis that the olfactory bulb provides trophic support to this region of the central nervous system.
KW - Lesion
KW - Nerve growth factor
KW - Olfactory
KW - Regeneration
UR - http://www.scopus.com/inward/record.url?scp=0031763044&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031763044&partnerID=8YFLogxK
U2 - 10.1016/S0736-5748(98)00016-1
DO - 10.1016/S0736-5748(98)00016-1
M3 - Article
C2 - 9881301
AN - SCOPUS:0031763044
SN - 0736-5748
VL - 16
SP - 527
EP - 538
JO - International Journal of Developmental Neuroscience
JF - International Journal of Developmental Neuroscience
IS - 6
ER -