Expression of tumor necrosis factor alpha and interleukin 1β in jejuna of volunteers after experimental challenge with Cryptosporidium parvum correlates with exposure but not with symptoms

P. Robinson, P. C. Okhuysen, C. L. Chappell, D. E. Lewis, I. Shahab, A. Janecki, A. Clinton White

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Jejunal biopsies from volunteers challenged with Cryptosporidium parvum were examined for tumor necrosis factor alpha (TNF-α) and interleukin (IL)-1β mRNA. Postchallenge biopsies from 15 of 28 (54%) volunteers expressed TNF-α; 14% expressed IL-1β. Cytokine expression did not correlate with enteric symptoms, suggesting that TNF-α and IL-1β are not key mediators of diarrhea in human cryptosporidiosis.

Original languageEnglish (US)
Pages (from-to)1172-1174
Number of pages3
JournalInfection and Immunity
Volume69
Issue number2
DOIs
StatePublished - 2001
Externally publishedYes

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Cryptosporidium parvum
Jejunum
Interleukin-1
Volunteers
Tumor Necrosis Factor-alpha
Cryptosporidiosis
Biopsy
Diarrhea
Cytokines
Messenger RNA

ASJC Scopus subject areas

  • Immunology

Cite this

Expression of tumor necrosis factor alpha and interleukin 1β in jejuna of volunteers after experimental challenge with Cryptosporidium parvum correlates with exposure but not with symptoms. / Robinson, P.; Okhuysen, P. C.; Chappell, C. L.; Lewis, D. E.; Shahab, I.; Janecki, A.; White, A. Clinton.

In: Infection and Immunity, Vol. 69, No. 2, 2001, p. 1172-1174.

Research output: Contribution to journalArticle

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AU - Janecki, A.

AU - White, A. Clinton

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