Expression Profiling of Circular RNAs and Micrornas in Heart Tissue of Mice with Alcoholic Cardiomyopathy

Yuqiao Yang, Hongmei Chen, Nina Ding, Shuo Wang, Zhantao Duan, Yochai Birnbaum, Yumei Ye, Jinqiao Qian

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background/Aims: Chronic heavy alcohol consumption may result in alcoholic cardiomyopathy. This study was designed to screen differentially expressed microRNAs and circular RNAs in heart tissue of mice with alcoholic cardiomyopathy to reveal the underlying molecular mechanism. Methods: Having established a murine alcoholic cardiomyopathy model, we screened differentially expressed microRNAs and circular RNAs in three heart samples from the alcohol-treated and control groups by high-throughput microarray analysis. We analyzed the function and biological signaling pathways of differentially expressed non-coding RNAs closely related to alcoholic cardiomyopathy using bioinformatics software to identify some mRNAs and their biological signaling pathways closely related to alcoholic cardiomyopathy. Results: Nineteen microRNAs and 265 circular RNAs were differentially expressed in the alcohol-treated group compared with the control group. After analyzing gene function and signaling pathways by bioinformatics software, we found that the differentially expressed mRNAs were associated with carbohydrate metabolism. Conclusions: Chronic alcohol consumption can change the non-coding RNA profile of heart tissue, which is closely related to the pathological mechanisms of alcoholic cardiomyopathy.

Original languageEnglish (US)
Pages (from-to)2284-2296
Number of pages13
JournalCellular Physiology and Biochemistry
Volume46
Issue number6
DOIs
StatePublished - May 1 2018

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Keywords

  • Alcoholic cardiomyopathy (ACM)
  • Circular RNAs
  • Competing endogenous RNA
  • MicroRNAs
  • Non-coding RNA

ASJC Scopus subject areas

  • Physiology

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