Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity

Daniel O'Reilly, Zachary J. Kartje, Eman A. Ageely, Elise Malek-Adamian, Maryam Habibian, Annabelle Schofield, Christopher L. Barkau, Kushal J. Rohilla, Lauren B. Derossett, Austin T. Weigle, Masad J. Damha, Keith T. Gagnon

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Biochemistry, Genetics and Molecular Biology

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Pharmacology, Toxicology and Pharmaceutical Science