Extent and magnitude of catecholamine surge in pediatric burned patients

Gabriela A. Kulp, David Herndon, Jong Lee, Oscar Suman, Marc G. Jeschke

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Increased catecholamine (CA) levels after severe burn are associated with stress, inflammation, hypermetabolism, and impaired immune function. The CA secretion profiles in burned patients are not well described. Mechanisms, duration, and extent of CA surge are unknown. The purpose of this large unicenter study was to evaluate the extent and magnitude of CA surge after severe burn in pediatric patients. Patients admitted between 1996 and 2008 were enrolled in this study. Twenty-four-hour urine collections were performed during acute hospitalization and up to 2 years postburn. Results from the samples collected from 12 normal, healthy volunteers were compared with the data from the burned patients. Relevant demographic and clinical information was obtained from medical records. Student t-test and one-way ANOVA were used to analyze the data where appropriate. Significance was accepted at P < 0.05. Four hundred thirteen patients were enrolled in this study; 17 patients died during acute hospitalization. Burn caused a marked stress and inflammatory response, indicated by massive tachycardia and elevated proinflammatory cytokines. In burned patients, CA levels are consistently and significantly modulated after burn when compared with the levels in normal, healthy volunteers. Catecholamine levels were significantly higher in boys compared with girls, correlated with burn size in burns greater than 40%, and were increased in older children. There were differences over time in survivors versus nonsurvivors, with CA levels significantly higher in nonsurvivors at two time points. Inflammatory cytokines show a similar profile during the study period. Our study gives clinicians a useful insight into the extent and magnitude of CA elevation to better design treatment strategies.

Original languageEnglish (US)
Pages (from-to)369-374
Number of pages6
JournalShock
Volume33
Issue number4
DOIs
StatePublished - Apr 2010

Fingerprint

Catecholamines
Pediatrics
Healthy Volunteers
Hospitalization
Cytokines
Urine Specimen Collection
Burns
Tachycardia
Medical Records
Survivors
Analysis of Variance
Demography
Students
Inflammation

Keywords

  • Burn
  • Catecholamine
  • Stress

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine
  • Medicine(all)

Cite this

Extent and magnitude of catecholamine surge in pediatric burned patients. / Kulp, Gabriela A.; Herndon, David; Lee, Jong; Suman, Oscar; Jeschke, Marc G.

In: Shock, Vol. 33, No. 4, 04.2010, p. 369-374.

Research output: Contribution to journalArticle

Kulp, Gabriela A. ; Herndon, David ; Lee, Jong ; Suman, Oscar ; Jeschke, Marc G. / Extent and magnitude of catecholamine surge in pediatric burned patients. In: Shock. 2010 ; Vol. 33, No. 4. pp. 369-374.
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