Extent of surgery for papillary thyroid cancer is not associated with survival

Mohamed Abdelgadir Adam, John Pura, Lin Gu, Michaela A. Dinan, Douglas Tyler, Shelby D. Reed, Randall Scheri, Sanziana A. Roman, Julie A. Sosa

Research output: Contribution to journalArticle

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Abstract

Objective: To examine the association between the extent of surgery and overall survival in a large contemporary cohort of patients with papillary thyroid cancer (PTC). Copyright

Background: Guidelines recommend total thyroidectomy for PTC tumors 1 cm, based on older data demonstrating an overall survival advantage for total thyroidectomy over lobectomy.

Methods: Adult patients with PTC tumors 1.04.0 cm undergoing thyroidectomy in the National Cancer Database, 19982006, were included. Cox proportional hazards models were applied to measure the association between the extent of surgery and overall survival while adjusting for patient demographic and clinical factors, including comorbidities, extrathyroidal extension, multifocality, nodal and distant metastases, and radioactive iodine treatment.

Results: Among 61,775 PTC patients, 54,926 underwent total thyroidectomy and 6849 lobectomy. Compared with lobectomy, patients undergoing total thyroidectomy had more nodal (7% vs 27%), extrathyroidal (5% vs16%), and multifocal disease (29% vs 44%) (all Ps 0.001). Median follow-up was 82 months (range, 60179 months). After multivariable adjustment, overall survival was similar in patients undergoing total thyroidectomy versus lobectomy for tumors 1.04.0 cm [hazard ratio (HR) = 0.96; 95% confidence interval (CI), 0.841.09); P = 0.54] and when stratified by tumor size: 1.02.0 cm [HR = 1.05; 95% CI, 0.881.26; P = 0.61] and 2.14.0 cm [HR = 0.89; 95% CI, 0.731.07; P = 0.21]. Older age, male sex, black race, lower income, tumor size, and presence of nodal or distant metastases were independently associated with compromised survival (P 0.0001).

Conclusions: Current guidelines suggest total thyroidectomy for PTC tumors 1 cm. However,we did not observe a survival advantage associated with total thyroidectomy compared with lobectomy. These findings call into question whether tumor size should be an absolute indication for total thyroidectomy.

Original languageEnglish (US)
Pages (from-to)601-607
Number of pages7
JournalAnnals of Surgery
Volume260
Issue number4
DOIs
StatePublished - 2014
Externally publishedYes

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Thyroidectomy
Survival
Neoplasms
Confidence Intervals
Guidelines
Neoplasm Metastasis
Papillary Thyroid cancer
Proportional Hazards Models
Iodine
Comorbidity
Demography
Databases

ASJC Scopus subject areas

  • Surgery

Cite this

Adam, M. A., Pura, J., Gu, L., Dinan, M. A., Tyler, D., Reed, S. D., ... Sosa, J. A. (2014). Extent of surgery for papillary thyroid cancer is not associated with survival. Annals of Surgery, 260(4), 601-607. https://doi.org/10.1097/SLA.0000000000000925

Extent of surgery for papillary thyroid cancer is not associated with survival. / Adam, Mohamed Abdelgadir; Pura, John; Gu, Lin; Dinan, Michaela A.; Tyler, Douglas; Reed, Shelby D.; Scheri, Randall; Roman, Sanziana A.; Sosa, Julie A.

In: Annals of Surgery, Vol. 260, No. 4, 2014, p. 601-607.

Research output: Contribution to journalArticle

Adam, MA, Pura, J, Gu, L, Dinan, MA, Tyler, D, Reed, SD, Scheri, R, Roman, SA & Sosa, JA 2014, 'Extent of surgery for papillary thyroid cancer is not associated with survival', Annals of Surgery, vol. 260, no. 4, pp. 601-607. https://doi.org/10.1097/SLA.0000000000000925
Adam, Mohamed Abdelgadir ; Pura, John ; Gu, Lin ; Dinan, Michaela A. ; Tyler, Douglas ; Reed, Shelby D. ; Scheri, Randall ; Roman, Sanziana A. ; Sosa, Julie A. / Extent of surgery for papillary thyroid cancer is not associated with survival. In: Annals of Surgery. 2014 ; Vol. 260, No. 4. pp. 601-607.
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abstract = "Objective: To examine the association between the extent of surgery and overall survival in a large contemporary cohort of patients with papillary thyroid cancer (PTC). CopyrightBackground: Guidelines recommend total thyroidectomy for PTC tumors 1 cm, based on older data demonstrating an overall survival advantage for total thyroidectomy over lobectomy.Methods: Adult patients with PTC tumors 1.04.0 cm undergoing thyroidectomy in the National Cancer Database, 19982006, were included. Cox proportional hazards models were applied to measure the association between the extent of surgery and overall survival while adjusting for patient demographic and clinical factors, including comorbidities, extrathyroidal extension, multifocality, nodal and distant metastases, and radioactive iodine treatment.Results: Among 61,775 PTC patients, 54,926 underwent total thyroidectomy and 6849 lobectomy. Compared with lobectomy, patients undergoing total thyroidectomy had more nodal (7{\%} vs 27{\%}), extrathyroidal (5{\%} vs16{\%}), and multifocal disease (29{\%} vs 44{\%}) (all Ps 0.001). Median follow-up was 82 months (range, 60179 months). After multivariable adjustment, overall survival was similar in patients undergoing total thyroidectomy versus lobectomy for tumors 1.04.0 cm [hazard ratio (HR) = 0.96; 95{\%} confidence interval (CI), 0.841.09); P = 0.54] and when stratified by tumor size: 1.02.0 cm [HR = 1.05; 95{\%} CI, 0.881.26; P = 0.61] and 2.14.0 cm [HR = 0.89; 95{\%} CI, 0.731.07; P = 0.21]. Older age, male sex, black race, lower income, tumor size, and presence of nodal or distant metastases were independently associated with compromised survival (P 0.0001).Conclusions: Current guidelines suggest total thyroidectomy for PTC tumors 1 cm. However,we did not observe a survival advantage associated with total thyroidectomy compared with lobectomy. These findings call into question whether tumor size should be an absolute indication for total thyroidectomy.",
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AU - Adam, Mohamed Abdelgadir

AU - Pura, John

AU - Gu, Lin

AU - Dinan, Michaela A.

AU - Tyler, Douglas

AU - Reed, Shelby D.

AU - Scheri, Randall

AU - Roman, Sanziana A.

AU - Sosa, Julie A.

PY - 2014

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N2 - Objective: To examine the association between the extent of surgery and overall survival in a large contemporary cohort of patients with papillary thyroid cancer (PTC). CopyrightBackground: Guidelines recommend total thyroidectomy for PTC tumors 1 cm, based on older data demonstrating an overall survival advantage for total thyroidectomy over lobectomy.Methods: Adult patients with PTC tumors 1.04.0 cm undergoing thyroidectomy in the National Cancer Database, 19982006, were included. Cox proportional hazards models were applied to measure the association between the extent of surgery and overall survival while adjusting for patient demographic and clinical factors, including comorbidities, extrathyroidal extension, multifocality, nodal and distant metastases, and radioactive iodine treatment.Results: Among 61,775 PTC patients, 54,926 underwent total thyroidectomy and 6849 lobectomy. Compared with lobectomy, patients undergoing total thyroidectomy had more nodal (7% vs 27%), extrathyroidal (5% vs16%), and multifocal disease (29% vs 44%) (all Ps 0.001). Median follow-up was 82 months (range, 60179 months). After multivariable adjustment, overall survival was similar in patients undergoing total thyroidectomy versus lobectomy for tumors 1.04.0 cm [hazard ratio (HR) = 0.96; 95% confidence interval (CI), 0.841.09); P = 0.54] and when stratified by tumor size: 1.02.0 cm [HR = 1.05; 95% CI, 0.881.26; P = 0.61] and 2.14.0 cm [HR = 0.89; 95% CI, 0.731.07; P = 0.21]. Older age, male sex, black race, lower income, tumor size, and presence of nodal or distant metastases were independently associated with compromised survival (P 0.0001).Conclusions: Current guidelines suggest total thyroidectomy for PTC tumors 1 cm. However,we did not observe a survival advantage associated with total thyroidectomy compared with lobectomy. These findings call into question whether tumor size should be an absolute indication for total thyroidectomy.

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