External validation of the Practical Risk Chart for the prediction of delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage

Paul M. Foreman, Michelle H. Chua, Mark R. Harrigan, Winfield S. Fisher, R. Shane Tubbs, Mohammadali Mohajel Shoja, Christoph J. Griessenauer

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

OBJECTIVE: Delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) occurs in approximately 30% of patients. The Practical Risk Chart was developed to predict DCI based on admission characteristics; the authors seek to externally validate and critically appraise this prediction tool. METHODS: A prospective cohort of aSAH patients was used to externally validate the previously published Practical Risk Chart. The model consists of 4 variables: clinical condition on admission, amount of cisternal and intraventricular blood on CT, and age. External validity was assessed using logistic regression. Model discrimination was evaluated using the area under the receiver operating characteristic curve (AUC). RESULTS: In a cohort of 125 patients with aSAH, the Practical Risk Chart adequately predicted DCI, with an AUC of 0.66 (95% CI 0.55-0.77). Clinical grade on admission and amount of intracranial blood on CT were the strongest predictors of DCI and clinical vasospasm. The best-fit model used a combination of the Hunt and Hess grade and the modified Fisher scale to yield an AUC of 0.76 (95% CI 0.675-0.85) and 0.70 (95% CI 0.602-0.8) for the prediction of DCI and clinical vasospasm, respectively. CONCLUSIONS: The Practical Risk Chart adequately predicts the risk of DCI following aSAH. However, the best-fit model represents a simpler stratification scheme, using only the Hunt and Hess grade and the modified Fisher scale, and produces a comparable AUC.

Original languageEnglish (US)
Pages (from-to)1530-1536
Number of pages7
JournalJournal of Neurosurgery
Volume126
Issue number5
DOIs
StatePublished - May 1 2017
Externally publishedYes

Fingerprint

Subarachnoid Hemorrhage
Brain Ischemia
Area Under Curve
ROC Curve
Logistic Models

Keywords

  • Aneurysm
  • Delayed cerebral ischemia
  • Ischemia
  • Practical Risk Chart
  • Prediction
  • Subarachnoid hemorrhage
  • Vascular disorders
  • Vasospasm

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Foreman, P. M., Chua, M. H., Harrigan, M. R., Fisher, W. S., Tubbs, R. S., Mohajel Shoja, M., & Griessenauer, C. J. (2017). External validation of the Practical Risk Chart for the prediction of delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage. Journal of Neurosurgery, 126(5), 1530-1536. https://doi.org/10.3171/2016.1.JNS152554

External validation of the Practical Risk Chart for the prediction of delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage. / Foreman, Paul M.; Chua, Michelle H.; Harrigan, Mark R.; Fisher, Winfield S.; Tubbs, R. Shane; Mohajel Shoja, Mohammadali; Griessenauer, Christoph J.

In: Journal of Neurosurgery, Vol. 126, No. 5, 01.05.2017, p. 1530-1536.

Research output: Contribution to journalArticle

Foreman, PM, Chua, MH, Harrigan, MR, Fisher, WS, Tubbs, RS, Mohajel Shoja, M & Griessenauer, CJ 2017, 'External validation of the Practical Risk Chart for the prediction of delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage', Journal of Neurosurgery, vol. 126, no. 5, pp. 1530-1536. https://doi.org/10.3171/2016.1.JNS152554
Foreman, Paul M. ; Chua, Michelle H. ; Harrigan, Mark R. ; Fisher, Winfield S. ; Tubbs, R. Shane ; Mohajel Shoja, Mohammadali ; Griessenauer, Christoph J. / External validation of the Practical Risk Chart for the prediction of delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage. In: Journal of Neurosurgery. 2017 ; Vol. 126, No. 5. pp. 1530-1536.
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AU - Tubbs, R. Shane

AU - Mohajel Shoja, Mohammadali

AU - Griessenauer, Christoph J.

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