Extinction of alpha-fetoprotein gene expression in somatic cell hybrids involves cis-acting DNA elements.

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alpha-Fetoprotein (AFP), a liver-specific protein, is extinguished in somatic cell hybrids formed by the fusion of mouse hepatoma cells (BWTG3) with rat fibroblast cells (JF1). Our studies show that the extinction of mouse AFP expression in these somatic cell hybrids may involve at least two cis-acting regulatory domains, i.e., the enhancer elements and a tissue-specific promoter region, which are located in the 5'-flanking region of the AFP gene.

Original languageEnglish (US)
Pages (from-to)2606-2609
Number of pages4
JournalMolecular and cellular biology
Issue number7
StatePublished - Jul 1987
Externally publishedYes


ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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