TY - JOUR
T1 - Extinction of alpha-fetoprotein gene expression in somatic cell hybrids involves cis-acting DNA elements.
AU - Widen, Steven
AU - Papaconstantinou, J.
PY - 1987/7
Y1 - 1987/7
N2 - alpha-Fetoprotein (AFP), a liver-specific protein, is extinguished in somatic cell hybrids formed by the fusion of mouse hepatoma cells (BWTG3) with rat fibroblast cells (JF1). Our studies show that the extinction of mouse AFP expression in these somatic cell hybrids may involve at least two cis-acting regulatory domains, i.e., the enhancer elements and a tissue-specific promoter region, which are located in the 5'-flanking region of the AFP gene.
AB - alpha-Fetoprotein (AFP), a liver-specific protein, is extinguished in somatic cell hybrids formed by the fusion of mouse hepatoma cells (BWTG3) with rat fibroblast cells (JF1). Our studies show that the extinction of mouse AFP expression in these somatic cell hybrids may involve at least two cis-acting regulatory domains, i.e., the enhancer elements and a tissue-specific promoter region, which are located in the 5'-flanking region of the AFP gene.
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U2 - 10.1128/MCB.7.7.2606
DO - 10.1128/MCB.7.7.2606
M3 - Article
C2 - 2441243
AN - SCOPUS:0023370679
SN - 0270-7306
VL - 7
SP - 2606
EP - 2609
JO - Molecular and cellular biology
JF - Molecular and cellular biology
IS - 7
ER -