Abstract
alpha-Fetoprotein (AFP), a liver-specific protein, is extinguished in somatic cell hybrids formed by the fusion of mouse hepatoma cells (BWTG3) with rat fibroblast cells (JF1). Our studies show that the extinction of mouse AFP expression in these somatic cell hybrids may involve at least two cis-acting regulatory domains, i.e., the enhancer elements and a tissue-specific promoter region, which are located in the 5'-flanking region of the AFP gene.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2606-2609 |
| Number of pages | 4 |
| Journal | Molecular and cellular biology |
| Volume | 7 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1987 |
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology
Fingerprint
Dive into the research topics of 'Extinction of alpha-fetoprotein gene expression in somatic cell hybrids involves cis-acting DNA elements.'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS