Extracorporeal membrane oxygenation in burn and smoke inhalation injury

Sven Asmussen, Dirk M. Maybauer, John F. Fraser, Kristofer Jennings, Shane George, Amar Keiralla, Marc O. Maybauer

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

A systematic review and meta-analysis was conducted to assess the level of evidence for the use of extracorporeal membrane oxygenation (ECMO) in hypoxemic respiratory failure resulting from burn and smoke inhalation injury. We searched any article published before March 01, 2012. Available studies published in any language were included. Five authors rated each article and assessed the methodological quality of studies using the recommendation of the Oxford Centre for Evidence Based Medicine (OCEBM). Our search yielded 66 total citations but only 29 met the inclusion criteria of burn and/or smoke inhalation injury. There are no available systematic reviews/meta-analyses published that met our inclusion criteria. Only a small number of clinical trials, all with a limited number of patients, were available. The overall data suggests that there is no improvement in survival for burn patients suffering acute hypoxemic respiratory failure, with the use of ECMO. ECMO run times of less than 200 h correlate with higher survival compared to 200 h or more. Scald burns show a tendency of higher survival than flame burns. In conclusion, the presently available literature is based on insufficient patient numbers; the data obtained and level of evidence generated are limited. The role of ECMO in burn and smoke inhalation injury is therefore unclear. However, ECMO technology and expertise have improved over the last decades. Further research on ECMO in burn and smoke inhalation injury is warranted.

Original languageEnglish (US)
Pages (from-to)429-435
Number of pages7
JournalBurns
Volume39
Issue number3
DOIs
StatePublished - May 2013

Fingerprint

Smoke Inhalation Injury
Extracorporeal Membrane Oxygenation
Burns
Respiratory Insufficiency
Survival
Meta-Analysis
Evidence-Based Medicine
Language
Clinical Trials
Technology
Research

Keywords

  • ALI
  • ARDS
  • ECMO
  • Meta-analysis
  • Respiratory failure
  • Systematic review

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine
  • Surgery

Cite this

Asmussen, S., Maybauer, D. M., Fraser, J. F., Jennings, K., George, S., Keiralla, A., & Maybauer, M. O. (2013). Extracorporeal membrane oxygenation in burn and smoke inhalation injury. Burns, 39(3), 429-435. https://doi.org/10.1016/j.burns.2012.08.006

Extracorporeal membrane oxygenation in burn and smoke inhalation injury. / Asmussen, Sven; Maybauer, Dirk M.; Fraser, John F.; Jennings, Kristofer; George, Shane; Keiralla, Amar; Maybauer, Marc O.

In: Burns, Vol. 39, No. 3, 05.2013, p. 429-435.

Research output: Contribution to journalArticle

Asmussen, S, Maybauer, DM, Fraser, JF, Jennings, K, George, S, Keiralla, A & Maybauer, MO 2013, 'Extracorporeal membrane oxygenation in burn and smoke inhalation injury', Burns, vol. 39, no. 3, pp. 429-435. https://doi.org/10.1016/j.burns.2012.08.006
Asmussen S, Maybauer DM, Fraser JF, Jennings K, George S, Keiralla A et al. Extracorporeal membrane oxygenation in burn and smoke inhalation injury. Burns. 2013 May;39(3):429-435. https://doi.org/10.1016/j.burns.2012.08.006
Asmussen, Sven ; Maybauer, Dirk M. ; Fraser, John F. ; Jennings, Kristofer ; George, Shane ; Keiralla, Amar ; Maybauer, Marc O. / Extracorporeal membrane oxygenation in burn and smoke inhalation injury. In: Burns. 2013 ; Vol. 39, No. 3. pp. 429-435.
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