Fabrication and surface chemistry of nanoscale bioarrays designed for the study of cytoskeletal protein binding interactions and their effect on cell motility

O. Cherniavskaya, C. J. Chen, E. Heller, E. Sun, J. Provezano, L. Kam, J. Hone, Michael Sheetz, S. J. Wind

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We have designed a system engineered to mimic biological spatial order. The system consists of nanoscale dots organized into hierarchical arrays in which structural parameters, such as spacing and orientation, are systematically varied. These arrays are used to probe the spatial distributions of binding sites in biomolecules. In this paper, we describe the fabrication process, including lithography and biofunctionalization, and we discuss issues related to surface chemistry that are critical to creating robust, biologically active nanoarrays.

Original languageEnglish (US)
Pages (from-to)2972-2978
Number of pages7
JournalJournal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures
Volume23
Issue number6
DOIs
StatePublished - Nov 1 2005
Externally publishedYes

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locomotion
Biomolecules
Binding sites
Surface chemistry
Lithography
Spatial distribution
chemistry
proteins
Fabrication
fabrication
cells
spatial distribution
lithography
spacing
interactions
probes
Protein Binding

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Electrical and Electronic Engineering

Cite this

Fabrication and surface chemistry of nanoscale bioarrays designed for the study of cytoskeletal protein binding interactions and their effect on cell motility. / Cherniavskaya, O.; Chen, C. J.; Heller, E.; Sun, E.; Provezano, J.; Kam, L.; Hone, J.; Sheetz, Michael; Wind, S. J.

In: Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures, Vol. 23, No. 6, 01.11.2005, p. 2972-2978.

Research output: Contribution to journalArticle

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AU - Sheetz, Michael

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