Fabrication and surface chemistry of nanoscale bioarrays designed for the study of cytoskeletal protein binding interactions and their effect on cell motility

O. Cherniavskaya; C. J. Chen; E. Heller; E. Sun; J. Provezano; L. Kam; J. Hone; M. P. Sheetz; S. J. Wind

doi:10.1116/1.2132332

Fabrication and surface chemistry of nanoscale bioarrays designed for the study of cytoskeletal protein binding interactions and their effect on cell motility

O. Cherniavskaya
, C. J. Chen
, E. Heller
, E. Sun
, J. Provezano
, L. Kam
, J. Hone
, M. P. Sheetz
, S. J. Wind

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

We have designed a system engineered to mimic biological spatial order. The system consists of nanoscale dots organized into hierarchical arrays in which structural parameters, such as spacing and orientation, are systematically varied. These arrays are used to probe the spatial distributions of binding sites in biomolecules. In this paper, we describe the fabrication process, including lithography and biofunctionalization, and we discuss issues related to surface chemistry that are critical to creating robust, biologically active nanoarrays.

Original language	English (US)
Pages (from-to)	2972-2978
Number of pages	7
Journal	Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures
Volume	23
Issue number	6
DOIs	https://doi.org/10.1116/1.2132332
State	Published - Nov 2005
Externally published	Yes

ASJC Scopus subject areas

Condensed Matter Physics
Electrical and Electronic Engineering

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10.1116/1.2132332

Cite this

Cherniavskaya, O., Chen, C. J., Heller, E., Sun, E., Provezano, J., Kam, L., Hone, J., Sheetz, M. P., & Wind, S. J. (2005). Fabrication and surface chemistry of nanoscale bioarrays designed for the study of cytoskeletal protein binding interactions and their effect on cell motility. Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures, 23(6), 2972-2978. https://doi.org/10.1116/1.2132332

Fabrication and surface chemistry of nanoscale bioarrays designed for the study of cytoskeletal protein binding interactions and their effect on cell motility. / Cherniavskaya, O.; Chen, C. J.; Heller, E. et al.
In: Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures, Vol. 23, No. 6, 11.2005, p. 2972-2978.

Research output: Contribution to journal › Article › peer-review

Cherniavskaya, O, Chen, CJ, Heller, E, Sun, E, Provezano, J, Kam, L, Hone, J, Sheetz, MP & Wind, SJ 2005, 'Fabrication and surface chemistry of nanoscale bioarrays designed for the study of cytoskeletal protein binding interactions and their effect on cell motility', Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures, vol. 23, no. 6, pp. 2972-2978. https://doi.org/10.1116/1.2132332

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title = "Fabrication and surface chemistry of nanoscale bioarrays designed for the study of cytoskeletal protein binding interactions and their effect on cell motility",

abstract = "We have designed a system engineered to mimic biological spatial order. The system consists of nanoscale dots organized into hierarchical arrays in which structural parameters, such as spacing and orientation, are systematically varied. These arrays are used to probe the spatial distributions of binding sites in biomolecules. In this paper, we describe the fabrication process, including lithography and biofunctionalization, and we discuss issues related to surface chemistry that are critical to creating robust, biologically active nanoarrays.",

author = "O. Cherniavskaya and Chen, \{C. J.\} and E. Heller and E. Sun and J. Provezano and L. Kam and J. Hone and Sheetz, \{M. P.\} and Wind, \{S. J.\}",

note = "Funding Information: We thank Louis Brus of the Columbia University Department of Chemistry for the use of his equipment. We are grateful to the Columbia University Center for Electron Transport in Molecular Nanostructures and the Center for Nanostructured Materials for making their processing facilities available for this work. We also thank R. Viswanathan and J. Bucchignano for enabling access to the electron beam lithography facilities at IBM{\textquoteright}s T. J. Watson Research Center. Oksana Cherniavskaya is supported in full by the Career Award at the Scientific Interface from the Burroughs Welcome Fund. ",

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AU - Provezano, J.

AU - Kam, L.

AU - Hone, J.

AU - Sheetz, M. P.

AU - Wind, S. J.

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Fabrication and surface chemistry of nanoscale bioarrays designed for the study of cytoskeletal protein binding interactions and their effect on cell motility

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