Fabrication of elastomer pillar arrays with modulated stiffness for cellular force measurements

S. Ghassemi, N. Biais, K. Maniura, S. J. Wind, Michael Sheetz, J. Hone

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The mechanical properties of a cell's environment can alter behavior such as migration and spreading, and control the differentiation path of stem cells. Here the authors describe a technique for fabricating substrates whose rigidity can be controlled locally without altering the contact area for cell spreading. The substrates consist of elastomeric pillar arrays in which the top surface is uniform but the pillar height is changed across a sharp step. Preliminary results demonstrate the effects on cell migration and morphology at the step boundary.

Original languageEnglish (US)
Pages (from-to)2549-2553
Number of pages5
JournalJournal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures
Volume26
Issue number6
DOIs
StatePublished - Dec 11 2008
Externally publishedYes

Fingerprint

Force measurement
elastomers
Elastomers
stiffness
Stiffness
Fabrication
fabrication
Substrates
Stem cells
cells
Rigidity
stem cells
rigidity
Mechanical properties
mechanical properties

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Electrical and Electronic Engineering

Cite this

Fabrication of elastomer pillar arrays with modulated stiffness for cellular force measurements. / Ghassemi, S.; Biais, N.; Maniura, K.; Wind, S. J.; Sheetz, Michael; Hone, J.

In: Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures, Vol. 26, No. 6, 11.12.2008, p. 2549-2553.

Research output: Contribution to journalArticle

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