Fabrication of nanoscale bioarrays for the study of cytoskeletal protein binding interactions using nanoimprint lithography

M. Schvartzman; K. Nguyen; M. Palma; J. Abramson; J. Sable; J. Hone; M. P. Sheetz; S. J. Wind

doi:10.1116/1.3043472

Fabrication of nanoscale bioarrays for the study of cytoskeletal protein binding interactions using nanoimprint lithography

M. Schvartzman
, K. Nguyen
, M. Palma
, J. Abramson
, J. Sable
, J. Hone
, M. P. Sheetz
, S. J. Wind

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The authors describe a high-throughput patterning process used to create arrays of molecular-scale features for the study of cytoskeletal protein binding interactions. The process uses a shadow-evaporated metal mask to facilitate lift-off of features defined by nanoimprint lithography. This simple and robust approach alleviates difficulties in pattern transfer of ultrasmall features and results in arrays of highly ordered sub-10 nm features which are then functionalized with extracellular matrix proteins. Application of these arrays is demonstrated in cell spreading assays.

Original language	English (US)
Pages (from-to)	61-65
Number of pages	5
Journal	Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures
Volume	27
Issue number	1
DOIs	https://doi.org/10.1116/1.3043472
State	Published - 2009
Externally published	Yes

ASJC Scopus subject areas

Condensed Matter Physics
Electrical and Electronic Engineering

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10.1116/1.3043472

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Schvartzman, M., Nguyen, K., Palma, M., Abramson, J., Sable, J., Hone, J., Sheetz, M. P., & Wind, S. J. (2009). Fabrication of nanoscale bioarrays for the study of cytoskeletal protein binding interactions using nanoimprint lithography. Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures, 27(1), 61-65. https://doi.org/10.1116/1.3043472

Schvartzman, M, Nguyen, K, Palma, M, Abramson, J, Sable, J, Hone, J, Sheetz, MP & Wind, SJ 2009, 'Fabrication of nanoscale bioarrays for the study of cytoskeletal protein binding interactions using nanoimprint lithography', Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures, vol. 27, no. 1, pp. 61-65. https://doi.org/10.1116/1.3043472

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title = "Fabrication of nanoscale bioarrays for the study of cytoskeletal protein binding interactions using nanoimprint lithography",

abstract = "The authors describe a high-throughput patterning process used to create arrays of molecular-scale features for the study of cytoskeletal protein binding interactions. The process uses a shadow-evaporated metal mask to facilitate lift-off of features defined by nanoimprint lithography. This simple and robust approach alleviates difficulties in pattern transfer of ultrasmall features and results in arrays of highly ordered sub-10 nm features which are then functionalized with extracellular matrix proteins. Application of these arrays is demonstrated in cell spreading assays.",

author = "M. Schvartzman and K. Nguyen and M. Palma and J. Abramson and J. Sable and J. Hone and Sheetz, \{M. P.\} and Wind, \{S. J.\}",

note = "Funding Information: This work was supported primarily by the National Science Foundation under Award No. NSF EF-05-07086, as well as by the National Institutes of Health through the NIH Roadmap for Medical Research under Award No. PN2 EY 016586. Additional support from the Nanoscale Science and Engineering Initiative of the National Science Foundation under NSF Award No. CHE-0641523 and by the New York State Office of Science, Technology, and Academic Research (NYSTAR)” is also gratefully acknowledged. The authors are grateful to the Columbia University Center for Electron Transport in Molecular Nanostructures and the Center for Nanostructured Materials for making their processing facilities available for this work.",

year = "2009",

doi = "10.1116/1.3043472",

language = "English (US)",

volume = "27",

pages = "61--65",

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AU - Abramson, J.

AU - Sable, J.

AU - Hone, J.

AU - Sheetz, M. P.

AU - Wind, S. J.

N1 - Funding Information: This work was supported primarily by the National Science Foundation under Award No. NSF EF-05-07086, as well as by the National Institutes of Health through the NIH Roadmap for Medical Research under Award No. PN2 EY 016586. Additional support from the Nanoscale Science and Engineering Initiative of the National Science Foundation under NSF Award No. CHE-0641523 and by the New York State Office of Science, Technology, and Academic Research (NYSTAR)” is also gratefully acknowledged. The authors are grateful to the Columbia University Center for Electron Transport in Molecular Nanostructures and the Center for Nanostructured Materials for making their processing facilities available for this work.

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Fabrication of nanoscale bioarrays for the study of cytoskeletal protein binding interactions using nanoimprint lithography

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