Facile and stereospecific synthesis of cis-3-(N'-arylureido)-2,3- dihydro-2-phenyl-1,2-benzoxaphosphole 2-oxides

Jia Zhou, Yongge Qiu, Kesheng Feng, Ruyu Chen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A simple method for the preparation of cis-3-(N'-arylureido)-2,3- dihydro-2-phenyl-1,2-benzoxaphosphole 2-oxides 7 in moderate to high yields consists in the three-component reaction of phenyldichlorophosphine with salicylaldehyde and arylureas in anhydrous benzene. The stereochemistry and the possible reaction mechanism of the cyclizations are also discussed. The results presented in this paper provide a new general and efficient approach to the novel organophosphorus heterocycles with the 3-substituted 2,3- dihydro-1,2-benzoxaphosphole 2-oxide ring system.

Original languageEnglish (US)
Pages (from-to)234-236
Number of pages3
JournalSynthesis
Issue number2
StatePublished - 1999
Externally publishedYes

Fingerprint

Oxides
Stereochemistry
Cyclization
Benzene
salicylaldehyde

Keywords

  • 2,3-dihydro-1,2-benzoxaphosphole 2- oxides
  • Mechanism
  • Organophosphorus heterocycles
  • Stereoselectivity

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Facile and stereospecific synthesis of cis-3-(N'-arylureido)-2,3- dihydro-2-phenyl-1,2-benzoxaphosphole 2-oxides. / Zhou, Jia; Qiu, Yongge; Feng, Kesheng; Chen, Ruyu.

In: Synthesis, No. 2, 1999, p. 234-236.

Research output: Contribution to journalArticle

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